慢性阻塞性肺疾病频繁急性加重表型气道阻力的研究  

Study on Airway Resistance in Patients with Chronic Obstructive Pulmonary Disease Experiencing Frequent Acute Exacerbations

作　　者：叶蕊 王翠红[1] 赵立[1] 朱丽华[1] 孙朋波[1] 高懿卓[1] YE Rui;WANG Cuihong;ZHAO Li;ZHU Lihua;SUN Pengbo;GAO Yizhuo(Department of Respiratory Medicine,Shengjing Hospital,China Medical University,Shenyang 110004,China)

机构地区：[1]中国医科大学附属盛京医院第一呼吸内科

出　　处：《中国医科大学学报》2019年第6期511-514,共4页Journal of China Medical University

基　　金：辽宁省自然科学基金(2015020548)

摘　　要：目的探讨慢性阻塞性肺疾病(COPD)频繁急性加重表型气道阻力的特点。方法选取2015年10月至2017年10月在中国医科大学附属盛京医院就诊的COPD稳定期患者,其中,频繁急性加重表型51例,年龄、性别相匹配的非频繁急性加重表型58例。检测各组第1秒用力呼气容积(FEV1)、残气容积/肺总量(RV/TLC)、气道阻力(Raw)和比气道传导率(sGaw)。结果同肺功能分级2组患者RV/TLC占预计值百分数(RV/TLC%pred)、Raw占预计值百分数(Raw%pred)和sGaw占预计值百分数(sGaw%pred)比较,差异无统计学意义(P>0.05)。频繁急性加重表型组,不同肺功能分级RV/TLC%pred、Raw%pred和sGaw%pred比较,差异有统计学意义(P<0.05),随着FEV1占预计值百分数(FEV1%pred)下降,RV/TLC%pred和Raw%pred升高,sGaw%pred下降。结论气道阻力改变与急性加重出现频繁程度并不相关,仅与气流阻塞FEV1%pred变化程度相关。Objective To analyze the characteristics of airway resistance in patients with chronic obstructive pulmonary disease experiencing frequent acute exacerbations according to the results of lung function tests.Methods From October 2015 to October 2017,stable COPD patients who were diagnosed in the Department of Respiratory Medicine in Shengjing Hospital included 51 frequent exacerbators and 58 non-frequent exacerbators without significant difference in age and sex.FEV1,RV/TLC,Raw,and sGaw were tested and compared.Results RV/TLC%pred,Raw%pred,and sGaw%pred were not significantly different between the frequent exacerbators group and non-frequent exacerbators group in the same GOLD classification level(P>0.05).In the frequent exacerbators group,RV/TLC%pred、Raw%pred,and sGaw%pred were significantly different in the different GOLD classification level.Conclusion Airway resistance was not correlated with the symptoms,especially the exacerbation frequency,but it was correlated with airflow obstruction FEV1%pred.

关 键 词：慢性阻塞性肺疾病 气道阻力 肺功能 

分 类 号：R56[医药卫生—呼吸系统]