GPBB、cTnI、CK、CKMB在急性心肌梗死伴糖尿病早期诊断中的临床应用价值  

The clinical value of GPBB, cTnI, CK and CKMB in early diagnosis of acute myocardial infarction with diabetes mellitus

作　　者：秦小霞[1] 武艳[1] 张丽[1] 靳萍奎[2] 白雪梅[1] 闫国超[1] QIN Xiaoxia;WU Yan;ZHANG Li;JIN Pingkui;BAI Xuemei;YAN Guochao(Department of Clinical Laboratory,The First Hospital of Hebei Medical University,Shijiazhuang 050031,Hebei,China;Department of Emergency Internal Medicine,The First Hospital of Hebei Medical University,Shijiazhuang 050031,Hebei,China)

机构地区：[1]河北医科大学第一医院检验科,河北石家庄050031 [2]河北医科大学第一医院急诊内科,河北石家庄050031

出　　处：《中南医学科学杂志》2019年第4期425-428,共4页Medical Science Journal of Central South China

摘　　要：分析心肌梗死伴糖尿病患者血清中糖原磷酸化酶同工酶BB(GPBB)、肌钙蛋白I(cTnI)、肌酸激酶(CK)、肌酸激酶同工酶(CKMB)水平的变化。结果显示糖尿病组、单纯急性心肌梗死组及急性心肌梗死伴糖尿病组患者血清中GPBB、cTnI、CK、CKMB、BNP及超敏C反应蛋白(Hs-CRP)水平明显升高(P<0.05),且急性心肌梗死伴糖尿病组患者与其他组相比差异均有显著性(P<0.05);与GPBB、cTnI、CK、CKMB单独检测相比,各项目联合检测急性心肌梗死伴糖尿病敏感度和特异性均明显升高(P<0.05)。因此,GPBB、cTnI、CK、CKMB联合检测在急性心肌梗死伴糖尿病早期诊断中具有重要的参考价值。The changes of serum levels of GPBB,cTnI,CK and CKMB in patients were analyzed.The Results showed that the serum levels of GPBB,cTnI,CK,CKMB,BNP and Hs-CRP in diabetic group,simple acute myocardial infarction group and acute myocardial infarction with diabetes mellitus group were significantly higher ( P <0.05),and there were significant differences between acute myocardial infarction with diabetes mellitus group and other groups ( P <0.05).Compared with GPBB,cTnI,CK,CKMB alone,the sensitivity and specificity of combined detection of acute myocardial infarction with diabetes mellitus were significantly increased ( P <0.05).So The combined detection of GPBB,cTnI,CK and CKMB has important reference value in the early diagnosis of acute myocardial infarction with diabetes mellitus.

关 键 词：肌钙蛋白I 肌酸激酶 肌酸激酶同工酶 急性心肌梗死 糖尿病 早期诊断 

分 类 号：R542.22[医药卫生—心血管疾病]