脾氨肽口服冻干粉在免疫功能失衡患者中的应用进展  

Process of Splenic Aminopeptide Oral Freeze-Dried Powder on Patients with Immune Dysfunction

作　　者：化怡纯 王婧[1] HUA Yichun;WANG Jing(Dept.of Oncology,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China)

机构地区：[1]首都医科大学附属北京友谊医院肿瘤中心

出　　处：《中国医院用药评价与分析》2019年第6期644-646,共3页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：国家自然科学基金(No.81000187)

摘　　要：人体在疾病状态下,可出现免疫功能失衡。常见的恶性肿瘤患者、反复呼吸道感染儿童患者和哮喘患者通常存在不同程度的免疫功能失衡,而免疫功能直接影响治疗结局和疾病转归。因此,针对上述患者,在治疗原发疾病的基础上,联合应用免疫调节剂有助于调整失衡的免疫功能,改善患者预后。脾氨肽口服冻干粉是由健康动物脾脏中提取的多肽及核苷酸类物质制成的,能够增强机体细胞免疫功能,促进T细胞向有功能的分型转化,同时可刺激多种免疫分子的释放。因此,脾氨肽口服冻干粉在免疫功能失衡患者中的合理应用,有助于缩短病程,提高患者的生活质量。本文主要就脾氨肽口服冻干粉改善免疫失衡患者预后的机制、临床应用等进行综述。Under the disease state, the immune system may have an imbalance of immune function. Patients with Common malignant tumor, children with recurrent respiratory infections, and asthma patients usually have varying degrees of immune dysfunction, and immune function directly affects outcomes of treatment and prognosis of disease. Therefore, for the above patients, combined application of immunomodulators on the basis of the treatment of primary diseases can help to adjust the imbalanced immune function and improve the prognosis of patients. Spleen aminopeptide oral freeze-dried powder is made of polypeptides and nucleotides extracted from the spleen of healthy animals, which can enhance the cellular immune function of the body, promote the transformation of T cells into functional typing, and stimulate the release of a variety of immune molecules. Therefore, the rational application of splenic aminopeptide oral freeze-dried powder in patients with immune dysfunction is helpful to shorten the course of disease and improve the quality of life. This article reviews the mechanism and clinical application of oral administration of splenic aminopeptide to improve the prognosis of patients with immune dysfunction.

关 键 词：脾氨肽口服冻干粉 免疫功能 失衡 

分 类 号：R979.5[医药卫生—药品]