孟鲁司特钠联合盐酸氮卓斯汀治疗过敏性鼻炎的疗效及对血清炎性因子、微量元素水平的影响  

Efficacy of Montelukast Combined with Azosteine Hydrochloride in Treatment of Allergic Rhinitis and its Effects on Serum Inflammatory Factors and Trace Element Levels

作　　者：黄秋菊[1] 魏欣[1] 林霞[1] 郑静[1] 粘家斌[1] HUANG Qiuju;WEI Xin;LIN Xia;ZHENG Jing;NIAN Jiabin(Dept.of Otolaryngology Head and Neck Surgery,Hainan People’s Hospital,Hainan Haikou 570311,China)

机构地区：[1]海南省人民医院耳鼻咽喉头颈外科

出　　处：《中国医院用药评价与分析》2019年第7期788-790,794,共4页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：国家自然科学基金地区科学基金项目(No.81760186);国家自然科学基金地区科学基金项目(No.81760187);海南省卫生计生科研项目(No.18A200022)

摘　　要：目的:探讨孟鲁司特钠联合盐酸氮卓斯汀治疗过敏性鼻炎的疗效及对血清炎性因子、微量元素水平的影响。方法:选取2017年2月至2018年9月海南省人民医院耳鼻咽喉头颈外科收治的过敏性鼻炎患者128例,按照随机数字表法分为对照组和观察组,每组64例。对照组患者给予孟鲁司特钠治疗,观察组患者在对照组的基础上加用盐酸氮卓斯汀鼻喷雾剂治疗。观察两组患者的临床疗效,治疗前后临床症状积分和血清白细胞介素6(IL-6)、白细胞介素8(IL-8)、白细胞介素-10(IL-10)、锌(Zn)、铜(Cu)、铁(Fe)、锰(Mn)水平及不良反应发生情况。结果:观察组患者的总有效率为89.06%(57/64),明显高于对照组的71.88%(46/64),差异有统计学意义(P<0.05);治疗后,观察组患者鼻痒、鼻塞、喷嚏、擤鼻积分及总评分明显低于对照组,差异均有统计学意义(P<0.05);治疗后,观察组患者血清IL-6、IL-8及IL-10水平明显优于对照组,差异均有统计学意义(P<0.05);治疗后,观察组患者血清Zn、Cu、Fe及Mn水平明显优于对照组,差异均有统计学意义(P<0.05);两组患者未发生明显不良反应。结论:孟鲁司特钠联合盐酸氮卓斯汀治疗过敏性鼻炎的疗效确切,安全性高,其作用机制可能与改善患者机体微量元素水平、抑制炎症反应有关。OBJECTIVE:To investigate the efficacy of montelukast combined with azosteine hydrochloride in treatment of allergic rhinitis and its effects on serum inflammatory factors and trace element levels.METHODS:Totally 128 patients with allergic rhinitis admitted into otolaryngology head and neck surgery of Hainan People’s Hospital from Feb.2017 to Sept.2018 were extracted to be divided into the observation group and the control group via the random number table,with 64 cases in each group.The control group was treated with montelukast,while the observation group received azoxetine hydrochloride on the basis of the control group.The clinical efficacy,clinical symptom scores,serum interleukin-6(IL-6),interleukin-8(IL-8),interleukin-10(IL-10),zinc(Zn),copper(Cu),ferritin(Fe),manganese(Mn)levels before and after treatment and adverse drug reactions of two groups were observed.RESULTS:The total effective rate of the observation group was 89.06%(57/64),significantly higher than that of the control group[71.88%(46/64)],the difference was statistically significant(P<0.05).After treatment,the scores of nasal itching,nasal congestion,sneezing and blowing and total scores in the observation group were significantly lower than those in the control group,with statistically significant differences(P<0.05).After treatment,the serum levels of IL-6,IL-8 and IL-10 in the observation group were significantly better than those in the control group(P<0.05).After treatment,the serum levels of Zn,Cu,Fe and Mn in the observation group were significantly better than those in the control group,and the differences were statistically significant(P<0.05).There were no significant adverse drug reactions in both groups.CONCLUSIONS:The efficacy of montelukast combined with azosteine hydrochloride in treatment of allergic rhinitis is significant with higher safety,its mechanism of action may be related to improving the trace element levels in patients and inhibiting inflammatory response.

关 键 词：孟鲁司特钠 盐酸氮卓斯汀 过敏性鼻炎 炎性因子 微量元素 

分 类 号：R974[医药卫生—药品]