甲氯芬酯联合无创颅内压监测用于急性脑出血的疗效及对患者脑血肿量、炎性因子的影响  

Efficacy of Meclofenoxate Combined with Noninvasive Intracranial Pressure Monitoring in Treatment of Acute Cerebral Hemorrhage and its Effects on Cerebral Hematoma Volume and Inflammatory Factors

作　　者：侯晓辉[1] 贾晓静[2] 王立江[1] 冯进[3] 贾叶娜 HOU Xiaohui;JIA Xiaojing;WANG Lijiang;FENG Jin;JIA Yena(Dept.of Neurosurgery,the Second Affiliated Hospital of Xingtai Medical College,Hebei Xingtai 054001;Dept.of Pharmacy,Xingtai Medical College,Hebei Xingtai 054000;Dept.of Neurosurgery,the First Affiliated Hospital of Xingtai Medical College,Hebei Xingtai 054001)

机构地区：[1]邢台医学高等专科学校第二附属医院神经外科,河北邢台054001 [2]邢台医学高等专科学校药学系,河北邢台054000 [3]邢台医学高等专科学校第一附属医院神经外科,河北邢台054001

出　　处：《中国医院用药评价与分析》2019年第7期818-821,共4页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：邢台市科技计划(No.2016ZC317)

摘　　要：目的:探讨甲氯芬酯联合无创颅内压监测用于急性脑出血的疗效及对患者脑血肿量、炎性因子的影响.方法:选取2016年7月至2018年3月邢台医专第二附属医院收治的急性脑出血患者124例,采用随机数字表法分为对照组和观察组,每组62例.对照组患者给予常规治疗及传统颅内压监测,观察组患者在常规治疗的基础上加用甲氯芬酯和无创颅内压监测,治疗时间均为1个月.观察两组患者的临床疗效,治疗前后日常生活能力(activities of daily living,ADL)评分、蒙特利尔认知评估量表(Montreal cognitive assessment,MoCA)评分、脑血肿量水平、炎性因子[白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)、超敏C反应蛋白(hs-CRP)及白细胞介素1(IL-1)]水平及不良反应发生情况.结果:观察组患者的总有效率为87.10%(54/62),明显高于对照组的54.84%(34/62),差异有统计学意义(P<0.05);治疗后,观察组患者ADL评分、MoCA评分明显高于对照组,脑血肿量明显低于对照组,差异均有统计学意义(P<0.05);治疗后,观察组患者IL-6、TNF-α、hs-CRP及IL-1水平明显低于对照组,差异均有统计学意义(P<0.05);两组患者均未见不良反应.结论:甲氯芬酯联合无创颅内压监测可显著提高急性脑出血患者的临床疗效,减轻炎症反应,提高患者认知能力、生活质量和日常生活能力.OBJECTIVE:To investigate the efficacy of meclofenoxate combined with noninvasive intracranial pressure monitoring in treatment of acute cerebral hematoma volume and its effects on cerebralhematoma volume and inflammatory factors.METHODS:Totally 124 patients with acute cerebral hemorrhage admitted into the Second Affiliated Hospital of Xingtai Medical College from Jul.2016 to Mar.2018 were extracted to be divided into the control group and the observation group via the random number table,with 62 cases in each group.The control group was given routine treatment and traditional intracranial pressure monitoring,while the observation group was treated with meclofenoxate combined with noninvasive intracranial pressure monitoring on the basis of routine treatment,the treatment time was 1 month.The clinical efficacy,activity of daily living(ADL)score,Montreal cognitive assessment(MoCA)score,cerebral hematoma volume,inflammatory factor[interleukin-6(IL-6)),tumor necrosis factor alpha(TNF-α),high-sensitivity C-reactive protein(hs-CRP)and interleukin-1(IL-1)levels before and after treatment and adverse drug reactions of two groups were observed.RESULTS:The total effective rate of the observation group was 87.10%(54/62),significantly higher than that of the control group[54.84%(34/62)],the difference was statistically significant(P<0.05).After treatment,the ADL score and MoCA score of the observation group were significantly higher than that of the control group,and the level of cerebral hematoma volume was significantly lower than that of the control group,the difference was statistically significant(P<0.05).After treatment,the levels of IL-6,TNF-α,hs-CRP and IL-1 in the observation group were significantly lower than those in the control group(P<0.05).No adverse drug reactions were observed in both groups.CONCLUSIONS:Meclofenoxate combined with noninvasive intracranial pressure monitoring can significantly improve the clinical efficacy of patients with acute cerebral hemorrhage,reduce the inflammation,improve patients�

关 键 词：急性脑出血 甲氯芬酯 无创颅内压监测 脑血肿量 炎性因子 

分 类 号：R971.7[医药卫生—药品]