四极离子阱阱内离子解离技术的研究进展  

Advances in Ion Dissociation within Quadrupole Ion Trap Mass Spectrometry

作　　者：楚士颖 谢洁 江游[2] 王方军[3] 翟睿 冯璐璐 龚晓云[2] 戴新华[2] 田地[1] 方向[2] 邱春玲[1] 黄泽建[2] CHU Shi-yingi;XIE Jie;JIANG You;WANG Fang-un;ZHAI Rui;FENG Lu-luz;GONG Xiao-yun;DAI Xin-hua;TIAN Di;FANG Xiang;QIU Chun-ling;HUANG Ze-ian(College of Instrument Science & Electrical Engineering,Jilin University,Changchun 130026,China;National Institute of Metrology,Beijing 100029,China;Dalian Institute of Chemical Physics,Chinese Academy of Sciences,Dalian 116023,China)

机构地区：[1]吉林大学仪器科学与电气工程学院,吉林长春130026 [2]中国计量科学研究院,北京100029 [3]中国科学院大连化学物理研究所,辽宁大连116023

出　　处：《质谱学报》2019年第4期391-400,I0004,共11页Journal of Chinese Mass Spectrometry Society

基　　金：国家重点计划项目(2016YFF0200504)资助

摘　　要：准确高效的离子解离技术对串联质谱分析方法具有非常重要的影响。四极离子阱可以存储离子,实现离子选择存储或逐出并进行多级质谱分析,适合各种解离技术在阱内的实施。由于生物质谱分析等研究工作对分子结构鉴定的需求,研究人员陆续开发了一系列阱内离子解离技术,推动了相关仪器与应用的发展。本文在离子阱几何结构和阱内离子运动规律的基础上,对是否依赖背景气体碰撞的两类阱内离子解离技术进行综述。其中,将依赖于背景气体碰撞的解离技术分为基于共振激发和非共振激发两类,归纳了每种解离技术的实施过程、解离特点及应用,并对各种解离技术存在的问题以及未来的研究方向进行总结。Accurate and efficient ion dissociation techniques have a very important impact on tandem mass spectrometry. The quadrupole ion traps are capable of storing ions and performing ions selective storage or ejection and multiple mass spectrometer analysis, which make it ideal for implementation of various dissociation within quadrupole ion trap techniques. A series of dissociation within quadrupole ion trap technologies have been developed for the need of molecular structure identification in research work such as mass spectrometry and it promoted the development of related instruments and applications at the same time. In this paper, the ion dissociation within quadrupole ion trap methods were reviewed, which included two categories depending on whether it depended on background gas based on a brief description of the geometric structure of ion trap and the motion law of ions in ion trap, among them, the dissociation technology depending on the background gas collision could be divided into two categories of resonance excitation and non-resonance excitation. This paper generalizes the implementation process, dissociation characteristics and applications of each dissociation technology, and summarizes the problems of various dissociation technologies and future research directions.

关 键 词：离子阱 阱内离子解离 背景气体 综述 

分 类 号：O657.63[理学—分析化学]