白细胞介素-6基因单核苷酸多态性与乙型肝炎患者肝癌易感性及临床预后的关系  

Relationship between interleukin -6 gene single nucleotide polymorphism and susceptibility to hepatocellular carcinoma and clinical prognosis in patients with hepatitis B

作　　者：王铁忠[1] 王征[2] 袁嘉阳 Wang Tiezhong;Wang Zheng;Yuan Jiayang(Department of Hepatobiliary Surgery,Linfen People's Hospital,Linfen,Shanxi 041000,China;Department of Critical Care Medicine, Linfen People 's Hospital, Linfen, Shanxi 041000, China;Scientific Research Office, Linfen People 's Hospital,Linfen,Shanxi 041000,China)

机构地区：[1]临汾市人民医院肝胆外科,山西省041000 [2]临汾市人民医院重症医学科,山西省041000 [3]临汾市人民医院科研办,山西省041000

出　　处：《中国基层医药》2019年第14期1670-1673,共4页Chinese Journal of Primary Medicine and Pharmacy

基　　金：山西省临汾市人民医院科研基金项目(KYXM2018105).

摘　　要：目的探讨白细胞介素-6单核基因多态性与乙型肝炎后肝癌易感性及临床预后的关系.方法选取临汾市人民医院2016年9月至2017年9月收治的乙型肝炎后肝癌患者100例(A组)作为研究对象,并以100健康人群(B组)作为对照,收集两组外周血,检测IL-6基因多态性,探讨IL-6基因多态性与患者乙型肝炎后肝癌发生的危险关系,并采用logistics回归分析探讨影响乙型肝炎后肝癌患者临床预后的风险因素.结果观察组IL-6rs13419896位点基因型C/T、T/T比例及等位基因T比例均高于对照组(均P<0.05),基因型C/C比例及等位基因C比例均低于对照组,以无肝癌家族史C/C基因型为参照,携带T基因患者肝癌风险比1.92、合并肝癌家族史风险比为2.01,以<5支吸烟的C/C基因型为参照,携带T基因患者肝癌风险比为1.92,合并经常吸烟风险比为2.16,肝癌家族史(P=0.023)、rs13419896(T/T)(P=0.017)是肝癌患者死亡、转移或复发的独立危险因素.结论IL-6基因rs13419896位点携带T基因是肝癌发生的风险因素,而基因型为(T/T)是肝癌患者预后不良的危险因素.Objective To investigate the relationship between interleukin-6 ( IL-6) polymorphism and susceptibility to hepatocellular carcinoma(HCC) and clinical prognosis after hepatitis B.Methods From September 2016 to September 2017,100 patients with HCC after hepatitis B admitted to Linfen People's Hospital were selected as the observation group,and 100 healthy people were selected as the control group.Peripheral blood samples of the two groups were collected.IL-6 gene polymorphisms were detected to explore the relationship between IL-6 gene poly-morphisms and the risk of HCC after hepatitis B.Logistic regression analysis was used to explore the risk factors of clinical prognosis in patients with HCC after hepatitis B.Results The genotype C/T,T/T ratio and allele T ratio of IL-6 rs13419896 locus in the observation group were higher than those in the control group(all P<0.05).The C/C genotype of occasional smoking was used as the reference.The risk ratio of HCC was 1.92,the risk ratio of combined family history of HCC was 2.01,the risk ratio of frequent smoking was 2.16.Family history of HCC (P=0.023) and rs13419896(T/T)(P=0.017) were independent risk factors for death,metastasis or recurrence.Conclusion IL-6 gene rs13419896 carrying T gene is a risk factor for HCC,and genotype( T/T) is a risk factor for poor prognosis in HCC patients.

关 键 词：乙型病毒肝炎 IL-6基因多态性 易感性 肝癌 炎性因子 单核基因 临床预后 

分 类 号：R512.62[医药卫生—内科学]