岩舒复方苦参注射液联合放疗治疗肺癌骨转移疼痛的疗效观察  

Observation on therapeutic effects Yanshu compound radix sophore injection for treatment of patients with bone metastasis pain of lung cancer

作　　者：魏世鸿[1] 祁月萧 董玉梅[1] 郭丽云[1] 宋海侠[1] 罗宏涛[1] 刘锐锋[1] 夏小军[1] Wei Shihong;Qi Yuexiao;Dong Yumei;Guo Liyun;Song Haixia;Luo Hongtao;Liu Ruifeng;Xia Xiaojun(Department of Radiation Oncology,Gansu Provincial Cancer Hospital,Lanzhou 730050,Gansu,China)

机构地区：[1]甘肃省肿瘤医院放疗科,甘肃兰州730050

出　　处：《中国中西医结合急救杂志》2019年第3期356-359,共4页Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care

基　　金：甘肃省科技厅技术研究与开发专项计划(2GS064-A43-020-16);甘肃省中医药管理局中医防治重大疾病科研项目(GZK-2014-76).

摘　　要：目的观察岩舒复方苦参注射液联合放疗治疗肺癌骨转移患者的临床效果.方法选择甘肃省肿瘤医院放疗科2014年1月至2018年12月收治的肺癌骨转移患者116例,58例患者采用三维适形放疗(3D-CRT)+唑来膦酸+羟考酮缓释片治疗(西医对照组),另58例在对照组治疗基础上加苦参注射液(中西联合组).两组均连续治疗10d为1个疗程,两个疗程中间休息1周,治疗2个疗程后评价疗效.观察两组治疗前后疼痛分级和Karnofsky功能状态(KPS)评分患者比例以及骨髓抑制情况.结果中西联合组治疗后无痛和轻度疼痛患者比例均显著低于西医对照组〔无痛:22.41%(13/58)比39.66%(23/58),轻度疼痛:10.35%(6/58)比46.55%(27/58)〕,中度疼痛和重度疼痛患者比例显著高于西医对照组〔中度:53.45%(31/58)比12.07%(7/58),重度:13.79%(8/58)比1.72%(1/58),均P<0.05〕.中西联合组治疗后KPS评分改善的患者比例明显多于西医对照组〔55.17%(32/58)比36.21%(21/58),均P<0.05〕,KPS评分稳定和下降的患者比例少于西医对照组〔稳定:18.97%(11/58)比27.59%(16/58);下降:25.86%(15/58)比36.21%(21/58)〕.中西联合组治疗后白细胞计数(WBC)、血红蛋白(Hb)、血小板计数(PLT)未表现出骨髓抑制(0度)患者比例均明显多于西医对照组〔WBC:77.59%(45/58)比36.21%(21/58),Hb:77.59%(45/58)比70.69%(41/58),PLT:58.62%(34/58)比32.76%(19/58),均P<0.05〕.结论复方苦参注射液联合放疗可减轻晚期肺癌患者骨转移疼痛和骨髓抑制,改善患者生活质量.Objective To observe the clinical effect of Yanshu compound radix sophore injection combined with radiotherapy in treatment of patients with bone metastases from lung cancer.Methods A total of 116 patients with bone metastases from lung cancer admitted to the Department of Radiation Oncology of Gansu Provincial Cancer Hospital from January 2014 to December 2018 were selected.The 58 patients were treated by using three-dimensional conformal radiotherapy(3D-CRT),zoledronic acid and oxycodone sustained-release tablets(control group);the others 58 patients were treated radix sphore injection on basis of control group(integrated Chinese and western medicine).The two groups were treated continuously for 10 days as 1 course of treatment,taking a rest for one week in the middle,then they took the second course of treatment;after the end of 2 courses,the therapeutic effects were evaluated in the two groups.The pain grading,Karnofsky functional status(KPS)score and myelosuppression were observed before and after treatment in two groups,respectively.Results The proportions of patients with painless and mild pain after treatment in the integrated Chinese and western medicine group were significantly lower than those in control group[painless:22.41%(13/58)vs.39.66%(23/58),mild pain:10.35%(6/58)vs.46.55%(27/58)],while the proportions of patients with moderate pain and severe pain in the integrated Chinese and western medicine group were significantly higher than those of the control group[moderate pain:53.45(31/58)vs.12.07%(7/58),severe pain:13.79%(8/58)vs 1.72%(1/58),both P<0.05].After treatment,the proportion of patients with improved KPS score in integrated Chinese and western medicine group was significantly higher than that in control group[55.17%(32/58)vs.36.21%(21/58),P<0.05],and the proportion of patients with stable and decreased KPS score were less than that of control group[stable KPS score:18.97%(11/58)vs.27.59%(16/58),decreased KPS score:25.86%(15/58)vs.36.21%(21/58)].The proportions of patients with blood cell co

关 键 词：肺癌 岩舒复方苦参注射液 骨转移 骨髓抑制 疼痛 中西医结合疗法 

分 类 号：R286.0[医药卫生—中药学]