广西防城港市中年男性同型半胱氨酸与代谢综合征相关性分析  

Relationship between serum homocysteine and metabolic syndrome in middle-aged men in Fangchenggang City

作　　者：黄奕铭 谭爱花[1] 张海英[1] 高勇[1] 陆峥 吴春雷 杨晓波[1] 莫曾南[1] 蒋永华[1] Huang Yiming;Tan Aihua;Zhang Haiying(Center for Genomic and Personalized Medicine,Guangxi Medical University,Nanning 530021)

机构地区：[1]广西医科大学基因组与个体化医学研究中心广西医科大学附属肿瘤医院

出　　处：《中国现代医药杂志》2019年第7期9-12,共4页Modern Medicine Journal of China

摘　　要：目的研究广西壮族自治区防城港市中年男性血清同型半胱氨酸(homocysteine,Hcy)与代谢综合征(Metabolic syndrome,MS)的相关性.方法研究对象为2009年9~12月防城港市随机抽样的4303名男性,采用回顾性分析方法收集代谢综合征及Hcy相关指标资料.运用多元线性回归方法和非条件Logistic回归方法进行分析.结果通过纳入排除标准,共484名受试者纳入研究.MS患者的Hcy平均水平高于非MS者[(16.81±5.74)μmol/L vs(15.40±4.00)μmol/L,P=0.028];并且MS患者的收缩压(r=0.161,P<0.001)、腰围(r=0.120,P=0.010)和总胆固醇(r=0.117,P=0.009)与Hcy呈正相关,但是高密度脂蛋白胆固醇与Hcy呈负相关(r=-0.092,P=0.047).Hcy与MS在校正年龄后,Hcy>16.56μmol/L是MS的危险因素[OR=1.904,95%CI(1.073,3.378)].结论Hcy>16.56μmol/L可能是MS的独立危险因素.Objective To investigate the relationship between serum Hcy levels and MS in middle-aged men in Fangchenggang City,Guangxi.Methods The association of MS and Hcy levels were analysed in 4 303 men who participated in the examination survey population-based Fangchenggang city from Sep to Dec in 2009.Results 484 men were chosen in the study.The serum Hcy levels of MS was higher than that of non-MS([16.81±5.74)μmol/L vs(15.40±4.00)μmol/L,P=0.028].Systolic blood pressure(r=0.161,P 0.001),waist circumference(r=0.120,P=0.010)and total cholesterol(r=0.117,P=0.009)were positively correlated with Hcy,but high density lipoprotein cholesterol was negatively correlated with Hcy(r=-0.092,P=0.047).After adjustment for age,serum Hcy16.56μmol/L was a risk factor for MS[OR=1.904,95%CI(1.073,3.378)].Conclusion Serum Hcy16.56μmol/L may be an indeperdent riskfactor for MS.

关 键 词：血清同型半胱氨酸 代谢综合征 

分 类 号：R589[医药卫生—内分泌]