硫酸镁联合拉贝洛尔治疗妊娠高血压综合征的临床效果及对血浆和红细胞内钙、镁离子浓度的影响  

Clinical effect of magnesium sulfate combined with labetalol in the treatment of pregnancy induced hypertension syndrome and its influence on concentration of calcium and magnesium ions in plasma and erythrocyte

作　　者：吕鑫荣 LV Xin-rong(Xi'an XD Group Hospital,Xi'an 710000,China)

机构地区：[1]西电集团医院

出　　处：《临床医学研究与实践》2019年第21期15-17,共3页Clinical Research and Practice

摘　　要：目的探讨硫酸镁联合拉贝洛尔治疗妊娠高血压综合征(PIHS)的临床效果及其对患者血浆和红细胞内钙、镁离子浓度的影响。方法将我院收治的96例PIHS患者按随机抽签原则分为参照组与试验组,各48例。两组均给予基础治疗措施,在此基础上参照组给予硫酸镁治疗,试验组给予硫酸镁联合拉贝洛尔治疗。比较两组治疗前、后血压控制效果、血浆和红细胞内钙、镁离子浓度、血液相关指标水平、临床疗效及不良反应发生情况。结果治疗前,两组患者血压(收缩压、舒张压)、血浆和红细胞内钙、镁离子浓度均无显著差异(P>0.05)。治疗后,两组患者血压(收缩压、舒张压)均降低,且试验组低于参照组(P<0.05);两组患者血浆钙离子、血浆镁离子及红细胞镁离子浓度均显著升高,且试验组高于参照组(P<0.05)。试验组治疗总有效率高于参照组(P<0.05)。治疗前,两组患者VEGF、GMP-140水平、PT及APTT无显著差异(P>0.05);治疗后,两组患者VEGF水平升高,PT及APTT延长,GMP-140水平降低,且试验组优于参照组(P<0.05)。试验组不良反应总发生率低于参照组(P<0.05)。结论硫酸镁联合拉贝洛尔治疗PIHS效果显著,可有效控制患者血压,调节机体钙、镁离子紊乱,改善血液高凝状态,减少不良反应发生情况。Objective To investigate the clinical effect of magnesium sulfate combined with labetalol in the treatment of pregnancy induced hypertension syndrome (PIHS) and its influence on the concentration of calcium and magnesium ions in plasma and erythrocyte. Methods Ninety-six PIHS patients admitted in our hospital were divided into reference group and experimental group according to the principle of random lottery, with 48 cases in each group. Both groups were given basic treatment measures, on this basis, the reference group was given magnesium sulfate treatment, and the experimental group was given magnesium sulfate combined with labetalol treatment. The effects of blood pressure control, the concentration of calcium and magnesium ions in plasma and erythrocyte, the levels of blood related indicators before and after treatment, the clinical efficacy and adverse reactions were compared between the two groups. Results Before treatment, there were no significant differences in blood pressure (systolic and diastolic blood pressure), plasma and erythrocyte calcium and magnesium ions concentrations between the two groups (P>0.05). After treatment, the blood pressure (systolic and diastolic blood pressure) of both groups decreased, and those in the experimental group were lower than the reference group (P<0.05);the plasma calcium ion, plasma magnesium ion and erythrocyte magnesium ion concentrations of the two groups increased significantly, and those in the experimental group were higher than the reference group (P<0.05). The total effective rate of treatment in the experimental group was higher than that in the reference group (P<0.05). Before treatment, there were no significant differences in the levels of VEGF, GMP-140, PT and APTT between the two groups (P>0.05). After treatment, the levels of VEGF increased and PT and APTT prolonged in the two groups, and the levels of GMP-140 decreased in the two groups, and those in the experimental group were better than the reference group (P<0.05). The total incidence of advers

关 键 词：拉贝洛尔 硫酸镁 妊娠高血压综合征 

分 类 号：R714.246[医药卫生—妇产科学]