环形RNA研究现状及展望  

Advances in and Prospect of circRNA

作　　者：曹培华 武丹彤 栾静[1] 王新蕾 刘伯男 马宁[1,2] CAO Peihua;WU Dantong;LUAN Jing;WANG Xinlei;LIU Bonan;MA Ning(Department of Biochemistry and Molecular Biology, Harbin Medical University,Harbin,150081,China;North Translational Medicine Research and Cooperation Center,Harbin,150081,China)

机构地区：[1]哈尔滨医科大学生物化学与分子生物学教研室,哈尔滨市150081 [2]北方转化医学研究合作中心,哈尔滨市150081

出　　处：《医学分子生物学杂志》2019年第4期395-400,共6页Journal of Medical Molecular Biology

摘　　要：环形RNA(circular RNA,circRNA)属于迄今发现的非编码RNA的当中的一种,是通过反向剪接(back spacing)形成的并以共价键形成环形结构的一类单链闭环分子。不同于经传统剪接(canonical splicing)形成的mRNA,经反向剪接形成的环形RNA不具有亍加帽结构和3'poly(A)尾结构,可抵抗RNaseR酶的降解。环形RNA可在多物种间广泛、稳定存在。随着高通量测序技术的发展,环形RNA相继被发现,在调控基因表达中发挥着重要功能,可参与多种疾病的发生发展过程。环形RNA以多种形式在转录水平发挥着重要的调控作用,具有巨大的研究前景。Circular RNAs ( circRNAs) are a novel class of single-stranded covalently closed RNA. CircRNAs are resistant to digestion to RNase R since it has neither 5' capping nor 3' polyA tail. CircRNAs is extensively and stably present in a great any species. With the development of high- throughput sequencing technology, more and more circRNAs are identified and found to play important roles in the regulation of genes and the development and progression of multiple diseases. CircRNA can regulate gene transcription in various ways and shows a significant prospect for research.

关 键 词：环形RNA 转录调控 非编码RNA 

分 类 号：R34[医药卫生—基础医学]