β-细辛醚鼻用微乳凝胶的制备及其释放度考察  

Study on Preparation of Micro-emulsion-Based Gel of β-asarone and Its Release in Vitro

作　　者：赵瑛[1] 王莉[1] ZHAO Ying;WANG Li(Tianyou Hospital Affiliated to Wuhan University of Science and Technology,Wuhan 430064,China)

机构地区：[1]武汉科技大学附属天佑医院

出　　处：《抗感染药学》2019年第5期743-747,共5页Anti-infection Pharmacy

摘　　要：目的:制备β-细辛醚微乳凝胶,并考察其质量和释放度。方法:以微乳区域大小为指标,并且以油相种类和混合乳化剂比例为因素,通过溶解度和伪三元相图筛选和制备微乳,选择合适凝胶基质制成微乳凝胶,并考察β-细辛醚微乳凝胶中β-细辛醚的含量、理化性质、稳定性和释放度。结果:选用Capryol-90为油相、吐温-80为乳化剂、丙三醇为助乳化剂,添加适量泊洛沙姆和卡波姆制成β-细辛醚微乳凝胶,各项考察指标均符合鼻腔给药要求,大鼠体内血药浓度(cmax)为0.65μg/mL。结论:所制备的β-细辛醚微乳凝胶具有稳定性高,释药快速持久的特点,可作为鼻腔内给药用剂型的制备及其使用。Objective: To study the preparation of micro-emulsion-based gel of β-asarone and its release in Vitro.Methods: The microemulsion area size was indicators, the types of oil phase and mixed emulsifier ratio were factor,the microemulsion prescription was screened using solubility and the pseudo-ternary phase diagram;the microemulsionbased gel was made from the suitable gel-base;the content determination, the physicochemical property, stability and pharmacokinetic of microemulsion-based gel were investigated. Results: The oil phase was Capryol-90, emulgator was Tween-80, co-emulsifier was glycerol, microemulsion-based gel was made from Poloxamer and Carbopol;the inspection indexes conformed to the requirements of the nasal drug delivery, and the cmaxwas 0.65 μg/mL in rat Vivo. Conclusion: The preparation of β-asarone microemulsion-based gels have characteristics of quality stabilization and the drug release rapid and everlasting. It can be used as the preparation and application of intranasal drug dosage form.

关 键 词：Β-细辛醚 微乳液 乳凝胶 释放度考察 

分 类 号：R283.6[医药卫生—中药学]