某儿童医院2018年417例药物不良反应的相关因素分析  

Analysis on Related Factors of 417 Cases of Adverse Drug Reaction in a Children’s Hospital in 2018

作　　者：姚华 王凤娇[1] 毛晨梅[1] YAO Hua;WANG Feng-jiao;MAO Chen-mei(Children's Hospital Affiliated to Suzhou University,Suzhou Jiangsu 215000,China)

机构地区：[1]苏州大学附属儿童医院

出　　处：《抗感染药学》2019年第5期808-811,共4页Anti-infection Pharmacy

摘　　要：目的:分析医院2018年上报的417例药物不良反应(ADR)的相关因素及其发生特点,为临床合理用药保证患儿的用药安全提供参考。方法:利用医院OA不良反应上报系统对2018年自愿呈报的、有效的417例ADRs报告,分析患儿性别、年龄和给药途径、涉及药物的品种、累及的系统/器官、关联性评价等相关因素和发生的特点。结果:417例有效ADRs报告中,其中新的、严重的不良反应占39.33%;男-女患儿之比为1.9∶1,年龄介于7 d^17岁之间,即<1岁64例为15.35%,>1~4岁192例为46.04%,>4~8岁99例为23.74%,>8~17岁62例为14.87%;静脉途径发生率为66.67%,非静脉途径发生率为33.33%;排名前三的药物类别主要是抗感染药物(36.21%)、中成药(15.35%)和电解质、营养补充药物(8.39%)。结论:2018年新的、严重的不良反应发生率高于2017年,说明医院ADRs报告质量的不断提高,规范抗感染药物、中成药及营养辅助用药物在儿科临床的使用,多方位的采取措施,确保患儿用药的安全性和有效性。Objective: To analyze the related factors and the occurrence characteristics of 417 cases of adverse drug reaction(ADR) reported by the hospital in 2018, and to provide a reference for clinical rational drug use to ensure the medication safety of children. Methods: 417 voluntary and effective ADRs reports in 2018 were collocted by the hospital OA adverse reaction reporting system. The sex, age, route of administration, variety of drugs involved, system/organ involved, correlation evaluation and other related factors were analyzed. Results: Among 417 cases of effective ADRs,new and severe ADRs accounted for 39.33%. The ratio of male to female children were 1.9:1, and the age ranged from 7 d to 17 years old, that is: 64 cases<1 years old were 15.35%, 192 cases>1 to 4 years old were 46.04%; 99 cases>4 to 8 years old were 23.74%, and 62 cases>8 to 17 years old were 14.87%. The incidence of venous route was 66.67% and that of non-venous route was 33.33%. The TOP 3 drug categories were anti-infective drugs(36.21%), proprietary Chinese medicines(15.35%), the electrolyte and nutritional supplements medication(8.39%). Conclusion: The incidence of new and serious ADRs in 2018 was higher than that in 2017, indicating the continuous improvement of the quality of hospital ADRs reports, the standardization of the clinical use of anti-infective drugs, proprietary Chinese medicines and nutritionassisted drugs in pediatrics, and the adoption of multi-directional measures to ensure the safety and effectiveness of medication for children.

关 键 词：儿童 药物不良反应 相关因素 发生特点 

分 类 号：R969.3[医药卫生—药理学]