高压氧联合拉贝洛儿治疗妊高征患者的疗效及其对血管内皮功能和母婴结局的影响  

Clinical efficacy of hyperbaric oxygen combined with labetalol in the treatment of gestational hypertension and its effect on vascular endothelial function and pregnancy outcomes

作　　者：顾洁 李妍芹[2] 李妍涵 Gu Jie;Li Yanqin;Li Yanhan(Department of Laboratory Animal Center,Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences,Tianjin 300020,China)

机构地区：[1]中国医学科学院血液病医院(血液学研究所)实验动物中心,天津300020 [2]兰州军区总医院妇产科

出　　处：《中华航海医学与高气压医学杂志》2019年第3期191-193,209,共4页Chinese Journal of Nautical Medicine and Hyperbaric Medicine

摘　　要：目的探究高压氧(HBO)联合拉贝洛儿治疗妊娠期高血压患者的临床疗效及其对血管内皮功能、母婴结局的影响。方法选取2016年6月至2018年6月兰州军区总医院妇产科收治住院的90例妊娠期高血压孕妇为研究对象,按照数字表法随机分为对照组(n=45)和观察组(n=45)。对照组给予拉贝洛儿药物支持治疗,观察组在对照组基础上联合HBO治疗。观察2组孕妇治疗前后血压的变化,比较剖宫产、产后出血、胎膜早破早产、胎儿呼吸窘迫、胎儿生长受限、新生儿窒息等妊娠结局及血管内皮功能的变化。结果观察组治疗后舒张压和收缩压[(84.4±6.2)mmHg和(133.3±11.2)mmHg]较对照组[(90.0±6.3)mmHg和(140.7±10.4)]mmHg均明显降低(P<0.05);观察组临床总有效率(95.6%)显著高于对照组(82.2%)(P<0.05)。观察组患者血清NO、ET-1水平明显优于对照组(P<0.05)。观察组患者剖宫产、产后出血、胎膜早破早产、胎儿呼吸窘迫、胎儿生长受限、新生儿窒息等不良妊娠结局发生率显著低于对照组,差异均有统计学意义(P<0.05)。结论HBO联合拉贝洛儿治疗能有效降低患者血压,同时改善血管内皮功能紊乱,减少不良妊娠结局的发生。Objective To explore the clinical efficacy of hyperbaric oxygen (HBO) combined with labetalol in the treatment of gestational hypertension and its effect on vascular endothelial function and pregnancy outcomes. Methods Ninety pregnant women with gestational hypertension admitted to the Department of Obstetrics and Gynecology in the General Hospital of Lanzhou from June 2016 to June 2018 were selected as study subjects, and were randomly divided into the control group (n=45) and the observation group (n=45). The control group was treated with labetalol, while the observation group received HBO in addition to the treatment received by the control group. The changes in blood pressure and endothelial function of the two groups were closely observed before and after treatment. The pregnancy outcomes including cesarean section, postpartum hemorrhage, premature rupture of membrane, fetal respiratory distress, fetal growth restriction and neonatal asphyxia were compared between the 2 groups. Results After treatment, the diastolic blood pressure (DBP) and systolic blood pressure (SBP) of the observation group [(84.4±6.2) mmHg,(133.3±11.2) mmHg] were significantly lower as compared with those of the control group [(90.0±6.3) mmHg,(140.7±10.4) mmHg](all P<0.05). Total efficacy of the observation group was 95.6%, which was significantly higher than 82.2% of the control group (P<0.05). NO and ET-1 levels in the observation group were obviously better than those of the control group (all P<0.05). The rates of cesarean section, postpartum hemorrhage, premature rupture of membrane, fetal respiratory distress, fetal growth restriction and neonatal asphyxia in the observation group were significantly lower than those of the control group, and statistical significance could be seen when comparisons were made between them (P<0.05). Conclusion HBO combined with labetalol in the treatment of gestational hypertension could effectively reduce patient blood pressure, improve endothelial dysfunction, and reduce the rate of adverse pre

关 键 词：高压氧 拉贝洛儿 妊娠期高血压 妊娠结局 

分 类 号：R714.246[医药卫生—妇产科学]