血清抗子宫内膜抗体、基质金属蛋白酶抑制剂-1和肿瘤相关抗原CA125与子宫内膜异位症的相关性研究  

Relationship between endometrium antibody, tissue inhibitor of metalloproteinase-1, tumor antigen CA125 markers and endometriosis

作　　者：苏芳[1] Su Fang(Department of Obstetrics and Gynecology, the People’sHospital of Linfen, Linfen 041000, China)

机构地区：[1]山西省临汾市人民医院妇产科,041000

出　　处：《中国实用医刊》2019年第10期81-84,共4页Chinese Journal of Practical Medicine

摘　　要：目的研究血清抗子宫内膜抗体(EMAb)、基质金属蛋白酶抑制剂-1(TIMP-1)和肿瘤相关抗原CA125与子宫内膜异位症(EM)的相关性及其对EM诊断和分期的价值。方法选取2017年1月至2018年6月在临汾市人民医院妇科治疗的180例EM患者为实验组,均接受妇科手术治疗。同时选取同期体检的健康人群100例为对照组。经参与实验者同意,采集实验组患者术前、术后3个月及对照组健康人群的血样,比较血清抗子宫内膜抗体(EMAb)、基质金属蛋白酶抑制剂-1(TIMP-1)及糖类抗原125(CA125)水平。本研究采用Spearman双变量检验对各项指标与EM发病及分期进行相关性分析评价,用受试者工作曲线(ROC)评价EMAb、TIMP-1与CA125指标对EM的诊断价值。结果术前实验组患者EMAb、TIMP-1与CA125水平均高于对照组(P均<0.01);术后实验组患者各项指标与较治疗前相比均显著改善(P均<0.05);术后实验组患者各项指标均高于对照组(P均<0.01)。Spearman相关性分析也显示,EM患者的EMAb、TIMP-1与CA125指标随着疾病分期提高也逐渐递增,EM患者的EMAb、TIMP-1及CA125指标与EM发病呈正相关(P均<0.01),与EM分期呈正相关(P均<0.05)。ROC曲线分析显示,TIMP-1(AUC=0.921)与CA125(AUC=0.936)比EMAb(AUC=0.851)对EM诊断具有更高的精确性。结论EM患者血清EMAb、TIMP-1与CA125水平高于健康人群,且这些指标血清值的高低与EM发病和疾病进展呈正相关。与术前相比,手术治疗对EM患者的这上述指标也有明显改善。Objective To study the relationship between endometrium antibody (EMAb), tissue inhibitor of metalloproteinase-1(TIMP-1), tumor antigen carbohydrate antigen 125 (CA125) markers and endometriosis(EM), and the diagnosis and staging of EM, and their value in diognosis and staging of EM. Methods A total of 180 patients with EM diagnosed in the People’s Hospital of Linfen from January 2017 to June 2018 were selected as experimental group. All EM patients in the experimental group received gynecological surgery. And 100 healthy subjects who received physical examination were selected as the control group. With consent from the participants of this study, serum samples were collected from study group both before surgery and 3 months after surgery as well as from control group. The difference of serum EMAb, TIMP-1, and CA125 markers in those groups were analyzed. Spearman’s two-variable test was used to evaluate the correlation between these markers and EM diagnosis and staging. The receiver operating curve (ROC) was used to evaluate the diagnostic value of EMAb, TIMP-1 and CA125 markers for EM. Results The EMAb, TIMP-1 and CA125 levels in the experimental group were significantly higher than those in the control group (P all<0.01). Surgical intervention significantly decreased those markers in experimental group compared with the value before surgery (P all<0.05), but they were still significantly higher than those in the control group (P all<0.01). And the serum levels of EMAb, TIMP-1 and CA125 markers were also positively correlated with the grade of EM disease. Spearman correlation analysis showed that EMAb, TIMP-1 and CA125 were positively correlated with EM onset (P all<0.01) and EM staging ( Pall<0.05). ROC curve analysis showed that TIMP-1 (AUC=0.921) and CA125 (AUC=0.936) have higher accuracy than EMAb (AUC=0.851) in diagnosing EM. Conclusions The serum levels of EMAb, TIMP-1 and CA125 in patients with EM are significantly higher than those in healthy people. The serum level of EMAb, TIMP-1 and CA125 makers

关 键 词：子宫内膜异位症 血清标志物 诊断 相关性 

分 类 号：R711.71[医药卫生—妇产科学]