早熟方治疗特发性中枢性性早熟患儿的临床疗效研究  

Therapeutic Effect of Zaoshu Recipe for Treatment of Children with Idiopathic Central Precocious Puberty

作　　者：石艳红[1] 范文萃[1] 徐雯[1] SHI Yan-Hong;FAN Wen-Cui;XU Wen(Guangzhou Municipal Hospital of Traditional Chinese Medicine,Guangzhou 510130 Guangdong,China)

机构地区：[1]广州市中医医院

出　　处：《广州中医药大学学报》2019年第7期982-987,共6页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：广东省中医药局面上项目(编号:20171223)

摘　　要：【目的】观察运用具有岭南特色药物的早熟方治疗特发性中枢性性早熟(ICPP)患儿的临床疗效。【方法】将80例ICPP患儿随机分为观察组和对照组,每组各40例。观察组给予具有滋阴补肾疏肝作用的中药早熟方治疗,对照组给予甲地孕酮片治疗,疗程3个月。观察2组患儿治疗前后第二性征如乳房与硬结大小和临床症状的改善情况,以及血清性激素水平[黄体生成素(LH)、卵泡刺激素(FSH)及雌二醇(E2)]与子宫容积和卵巢大小的变化情况,并评价2组的疗效和安全性。【结果】(1)治疗3个月后,观察组总有效率为92.5%,对照组为75.0%,观察组的疗效明显优于对照组,差异有统计学意义(P<0.05)。(2)治疗后,2组患儿乳房与硬结大小均较治疗前明显缩小(P<0.05),且观察组在缩小乳房与硬结大小方面均明显优于对照组(P<0.01)。(3)治疗后,观察组各项临床症状积分均较治疗前改善(P<0.05),而对照组仅急躁易怒及二便情况有改善(P<0.05),观察组在改善各项临床症状积分方面均明显优于对照组(P<0.05或P<0.01)。(4)治疗后,2组患儿血清E2水平均较治疗前明显下降(P<0.05),而血清FSH和LH水平也较治疗前有所下降,但差异均无统计学意义(P>0.05);组间比较,观察组在降低血清E2水平方面优于对照组(P<0.05)。(5)治疗后,观察组患儿的子宫容积和2组患儿的双侧卵巢均较治疗前有所缩小,但差异均无统计学意义(P>0.05);组间比较,观察组在缩小子宫容积方面优于对照组(P<0.05)。(6)治疗过程中,2组患儿均无明显不良反应情况发生。【结论】运用中药早熟方治疗ICPP患儿,具有较好疗效,对于改善临床症状,延缓青春期启动有一定的作用。Objective To observe the therapeutic effect of Zaoshu Recipe(a compound recipe mainly composed of herbs from Lingnan region with the actions of nourishing Yin, tonifying kidney and soothing liver) for the treatment of children with idiopathic central precocious puberty(ICPP). Methods Eighty ICPP patients were randomized into observation group and control group,40 cases in each group. The observation group was treated with Zaoshu Recipe orally,and the control group was treated with Megestrol Acetate Tablets orally. The treatment covered 3 months. Before and after treatment, the secondary sexual characteristics such as breast volume and scleroma size were monitored,the relief of the clinical symptoms was observed,serum levels of sex hormones such as luteinizing hormone(LH),follicle-stimulating hormone(FSH)and estradiol(E2)were detected,and uterine volume and ovary size were examined. After treatment,the clinical efficacy and safety in the two groups were compared. Results(1)After treatment for 3 months,the total effective rate of the observation group was92.5% and that of the control group was 75.0%,and the difference was significant(P<0.05),indicating that the clinical effect of the observation group being superior to that of the control group.(2)After treatment, breast volume and scleroma size in the two groups were much reduced(P<0.05 compared with those before treatment),the reduction in the observation group being superior to that in the control group(P<0.01).(3)After treatment,the scores of clinical symptoms in the observation group were much decreased(P<0.05 compared with those before treatment),and in the control group,only impatience and irritability as well as stool and urine were relieved(P<0.05),the relief of the clinical symptoms in the observation group being superior to that in the control group(P<0.05 or P<0.01).(4)After treatment,serum E2 level in the two groups was much decreased(P<0.05 compared with that before treatment),and serum FSH and LH level only showed a decreasing trend(P>0.05);the inter

关 键 词：早熟方 特发性中枢性性早熟(ICPP) 滋阴补肾疏肝 

分 类 号：R259.85[医药卫生—中西医结合]