针药并举治疗湿热蕴结型痛风的临床研究  

Clinical Study on Combination of Acupuncture and Chinese Medicine in Treating Gouty with Damp-heat Accumulation Type

作　　者：陈安娜 邹练强 张剑勇[2] 张燕英[2] CHEN An-Na;ZOU Lian-Qiang;ZHANG Jian-Yong;ZHANG Yan-Ying(The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen 518033 Guangdong,China;Shenzhen Traditional Chinese Medicine Hospital, Shenzhen 518033 Guangdong,China)

机构地区：[1]广州中医药大学第四临床医学院,广东深圳518033 [2]深圳市中医院,广东深圳518033

出　　处：《广州中医药大学学报》2019年第7期1003-1007,共5页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：深圳市医疗卫生“三名工程”项目(编号:SZSM201612080);深圳市科创委基础研究(自由探索)基金(编号:JCYJ20160428181150110)

摘　　要：【目的】探讨针刺联合湿热痹泰颗粒剂治疗湿热蕴结型痛风的临床疗效。【方法】将120例湿热蕴结型痛风患者随机分为对照组和治疗组,每组各60例。对照组给予湿热痹泰颗粒剂口服,治疗组给予湿热痹泰颗粒剂联合针刺治疗,4周为1个疗程,共治疗2个疗程。观察2组患者治疗前后中医证候积分、血尿酸浓度(UA)和血沉(ESR)的变化情况,并评价其临床疗效。【结果】(1)治疗后,2组患者各项中医证候积分及总积分均明显改善,且治疗组在改善关节疼痛、关节肿胀、皮肤红热、屈伸不利等证候积分及总积分方面明显优于对照组(P<0.05);(2)临床疗效比较:治疗组总有效率为88.33%,对照组为70.00%,治疗组总有效率明显高于对照组,差异有统计学意义(P<0.05);(3)治疗后,2组患者UA和ESR水平均明显改善,且治疗组的改善作用更为明显(P<0.05)。(4)治疗组疗程结束后0.5、1、3、6个月的复发率分别为0.0%、1.6%、3.3%和6.6%,均略低于对照组的1.6%、3.3%、8.3%和13.3%,但组间比较,差异均无统计学意义(P> 0.05);(5)治疗组不良反应发生率为8.1%,略低于对照组的11.4%,但组间比较,差异无统计学意义(P> 0.05)。【结论】针刺联合湿热痹泰颗粒剂口服治疗湿热蕴结型痛风临床疗效优于单纯湿热痹泰颗粒剂口服治疗,且复发率更低,不良反应更少。Objective To explore the therapeutic effects of acupuncture combined with Shire Bitai Granules on gouty with damp- heat accumulation type. Methods One hundred and twenty gouty patients with damp- heat accumulation type were randomly divided into control group and treatment group, 60 cases in each group. The control group was given oral use of Shire Bitai Granules, and the treatment group was given oral use of Shire Bitai Granules combined with acupuncture.Four weeks constituted one treatment course, and the treatment lasted 2 courses. Before and after treatment, the scores of each traditional Chinese medicine symptom and their overall scores, blood uric acid, and erythrocyte sedimentation rate in the two groups were observed. And the clinical efficacy was evaluated after treatment. Results (1) The scores of each traditional Chinese medicine sympton and overall scores in the two groups were obviously relieved after treatment, and the effect on improving the scores of joint pain, joint swelling, red and hot skin, and retarded flexion and extension as well as the orerall scores in the treatment group were superior to that in the control group (P < 0.05), but there was no significant difference in oral dryness and restlessness symptoms between the two groups (P > 0.05).(2)The effective rate was 88.33% in the treatment group, was 70.00% in the control group, and the effective rate in the treatment was obviously higher than that in the control group, the difference being statistically significant(P < 0.05).(3)The levels of blood uric acid and erythrocyte sedimentation rate were decreased in the two groups after treatment, the decrease in the treatment group was more significant (P < 0.05).(4) The recurrence rate in the treatment group 0.5, 1, 3, 6 months after the completion of treatment was 0.0%, 1.6%, 3.3%, 6.6%, respectively, mildly lower than that in the control group(1.6%, 3.3%, 8.3%, 13.3%, respectively), the difference being insignificant(P > 0.05).(5) The incidence of adverse reaction in the treatment group was

关 键 词：湿热痹泰颗粒剂 针刺疗法 湿热蕴结 痛风 临床观察 

分 类 号：R246.1[医药卫生—针灸推拿学]