金翘片体内抗甲型H3N2流感病毒及禽流感病毒H9N2作用研究  

Effects of Jinqiao Tablets on Anti-influenza A(H3N2) Virus and Anti-avian Influenza Virus H9N2 in Vivo

作　　者：张美义[1] 何家靖[1] 杨子峰[2] 杨兆丽 杨家庆[1] 詹利之[1] 曾庆慕 冯丽玲[1] 李国桥[1] 朱宇同[1] ZHANG Mei-Yi;HE Jia-Jing;YANG Zi-Feng;YANG Zhao-Li;YANG Jia-Qing;ZHAN Li-Zhi;ZENG Qing-Mu;FENG Li-Ling;LI Guo-Qiao;ZHU Yu-Tong(Institute of Tropical Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510405 Guangdong,China;Institute of Respiratory Infectious Disease, Guangzhou Medical University, Guangzhou 510000 Guangdong,China)

机构地区：[1]广州中医药大学热带医学研究所,广东广州510405 [2]广州医科大学广州呼吸道疾病研究所,广东广州510000

出　　处：《广州中医药大学学报》2019年第7期1064-1068,共5页Journal of Guangzhou University of Traditional Chinese Medicine

摘　　要：【目的】探讨金翘片体内抗甲型H3N2流感病毒及禽流感病毒H9N2的作用。【方法】分别以甲型H3N2流感病毒与禽流感病毒H9N2感染小鼠为模型,以小鼠肺指数及肺指数抑制率为评价指标,考察金翘片抗甲型H3N2流感病毒及抗禽流感病毒H9N2的作用,并观察金翘片的解热、镇痛、抗炎作用。【结果】金翘片具有明显的抑制甲型H3N2流感病毒致肺病变作用(P <0.05或P <0.01),抑制率随剂量增大而增大,呈量效关系;同时也对禽流感病毒H9N2感染鼠肺病变表现出明显的抑制作用(P<0.01)。并具有显著的解热、镇痛、抗炎作用。【结论】金翘片在体内具有显著的抗甲型H3N2流感病毒、抗禽流感病毒H9N2及解热、镇痛、抗炎作用。Objective To explore the effects of Jinqiao Tablets on anti-influenza A (H3N2) virus and anti-avian influenza virus H9N2 in vivo. Methods The mice infected seperately with influenza A(H3N2) virus and avian influenza virus H9N2 were used as the models. The lung index and lung- index inhibition rate in mice were examined to investigate the anti- virus effects of Jinqiao Tablets against influenza A (H3N2) virus and avian influenza virus H9N2. In addition, the antipyretic, analgesic, and anti- inflammatory effects of Jinqiao Tablets were observed. Results The pulmonary lesions induced by influenza A (H3N2) virus in mice were obviously inhibited by Jinqiao Tablets (P < 0.05 or P < 0.01), and the inhibition rate was increased with dosage increasing, which showed a dose- effect relationship. Meanwhile, the pulmonary lesions induced by avian influenza virus H9N2 in mice were also inhibited by Jinqiao Tablets (P < 0.01). Moreover, Jinqiao Tablets had antipyretic, analgesic, and anti- inflammatory effects. Conclusion Jinqiao Tablets have significant anti- influenza A virus H3N2 and anti-avian influenza virus H9N2 actions, as well as antipyretic, analgesic, anti-inflammatory effects in vivo.

关 键 词：金翘片 甲型H3N2流感病毒 禽流感病毒H9N2 疾病模型 动物 小鼠 大鼠 

分 类 号：R285.5[医药卫生—中药学]