几种血液指标与冠心病的相关性分析  

Correlation Analysis of Several Blood Indexes and Coronary Heart Disease

作　　者：赵俊伟[1] 孟宪春[1] 张文才[2] Zhao Junwei;Meng Xianchun;Zhang Wencai(Clinical Laboratory&Department of Cardiology,The First Affiliated Hospital of Zhengzhou University,Henan 450052,China)

机构地区：[1]郑州大学第一附属医院检验科,450052 [2]郑州大学第一附属医院心内科,450052

出　　处：《医学研究杂志》2019年第8期46-51,共6页Journal of Medical Research

基　　金：国家自然科学基金资助项目(81501715)

摘　　要：目的探讨几种血液指标与冠心病的关系,为冠心病的临床诊疗提供实验依据。方法回顾性收集50例健康对照者及112例冠心病患者。比较组间临床资料、血常规和生化实验室指标,多因素Logistic回归筛选冠心病危险因素,受试者工作特征(ROC)曲线评价这些血液指标对冠心病的预测价值。结果冠心病组年龄、血压、入院时平均血小板体积(MPV)、红细胞分布宽度(RDW)、中性粒细胞淋巴细胞比值(NLR)、胱抑素-C(CYS-C)、甘油三酯(TG)、尿素(UREA)水平均高于对照组(P<0.01),其预测冠心病的ROC曲线下面积分别为0.818、0.679、0.706、0.683、0.656、0.785、0.858、0.771;冠心病组患者入院时血红蛋白(Hb)、红细胞压积(HCT)、红细胞计数(RBC)、淋巴细胞单核细胞比值(LMR)水平则低于对照组(P<0.05),其预测冠心病的ROC曲线下面积分别为0.719、0.716、0.733、0.813。Logistic回归分析显示,年龄、高血压、入院时Hb、RBC、LMR、MPV、TG、UREA为冠心病的危险因素,多因素联合预测冠心病的ROC曲线下面积为0.973(95%CI:0.950~0.996,P=0.000),预测临界值为0.388,敏感度为87.9%,特异性为96.0%。结论患者年龄、高血压、入院时Hb、RBC、LMR、MPV、TG、UREA与冠心病的发生密切相关,联合分析可作为预测冠心病的临床指标之一。Objective To explore the relationship between several blood indexes and coronary heart disease,and to provide experimental basis for clinical diagnosis and treatment of coronary heart disease.Methods Fifty healthy control cases and 112 patients with coronary heart disease were retrospectively collected.The clinical data,blood routine examination and biochemical analysis were compared.Multivariate Logistic regression was screened for risk factors of coronary heart disease,and the predicted value of these blood indexes on coronary heart disease was evaluated by the receiver operating characteristic (ROC) curve.Results The age,blood pressure,mean platelet volume (MPV),red blood cell distribution width (RDW),neutrophil lymphocyte ratio (NLR),cystatin-C (CYS-C),triglyceride (TG),UREA levels in patients with coronary heart disease,were higher than that in healthy controls ( P <0.01),and the area under ROC curve were 0.818,0.679,0.706,0.683,0.656,0.785,0.858,0.771,respectively.Haemoglobin (Hb),hematocrit (Hct),red blood cell (RBC),and lymphocyte monocyte ratio (LMR) levels in patients with coronary heart disease were lower than that in healthy controls ( P <0.05),and the area under ROC curve were 0.719,0.716,0.733,0.813,respectively.The Logistic regression analysis showed that age,high blood pressure,Hb,RBC,LMR,MPV,TG,UREA were the risk factors of coronary heart disease,and the area under ROC curve based on these multiple factors for coronary heart disease was 0.973 (95%CI:0.950-0.996,P =0.000).The cutoff value of the prediction was 0.388,with the sensitivity 87.9% and the specificity 96.0%.Conclusion The age,high blood pressure,HB,RBC,LMR,MPV,TG,UREA are closely related to the coronary heart disease,and combined analysis can be used as one of the clinical indexes for predicting coronary heart disease.

关 键 词：冠心病 多因素Logistic回归 ROC曲线 

分 类 号：R541.4[医药卫生—心血管疾病]