玄参有机氯农药残留概貌及其限量标准研究  

Study on Profile of Residues of Organochlorine Pesticides in Scrophulariae Radix and Its Limit Standard

作　　者：梁慧慧 李龙[1,2] 张喜利 朱俊平[1,2,3] 文雯 毛妍[1,2,3] 周小江 李玲 陈乃宏 刘文龙 LIANG Huihui;LI Long;ZHANG Xili;ZHU Junping;WEN Wen;MAO Yan;ZHOU Xiaojiang;LI Ling;CHEN Naihong;LIU Wenlong(College of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China;Changde Affiliated Hospital, Hunan University of Chinese Medicine, Changde 415600, China;Hunan Key Laboratory of Druggabilityand Preparation Modification of Traditional Chinese Medicine, Changsha 410208, China;Hunan EngineeringTechnology Research Center of Standardization and Function of Chinese Medicine Decoction Pieces, Changsha410208, China;Drug Church (Hunan) Pharmaceutical Co., Ltd., Changde 415600, China)

机构地区：[1]湖南中医药大学药学院,湖南长沙410208 [2]湖南中医药大学附属常德医院,湖南常德415600 [3]中药成药性与制剂制备湖南省重点实验室,湖南长沙410208 [4]湖南省中药饮片标准化及功能工程技术研究中心,湖南长沙410208 [5]药圣堂(湖南)制药有限公司,湖南常德415600

出　　处：《中国中医药信息杂志》2019年第8期71-75,共5页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家自然科学基金(81874344);国家中药标准化项目(ZYBZH-Y-HUN-24);湖南省科技计划项目(2017NK2261);湖南省中医药科研计划项目(2019104);湖南省教育厅科研优秀青年项目(15B174);湖南中医药大学开发基金(kfjj2018010)

摘　　要：目的获得玄参药材及饮片有机氯农药残留概貌,建立玄参有机氯农药残留的限量标准。方法采用快速气相色谱法检测全国范围内10个代表产地的玄参药材及7个产地(30批次)玄参饮片中21种有机氯农药残留量,考察99%置信区间,制定玄参有机氯农药残留的限量标准。结果玄参样品中21种有机氯农药残留量为0.000 1~0.077 7μg/g,其中六六六、七氯、硫丹占农药残留总量的93%~96%,拟定了玄参中有机氯农药残留国家限量标准。结论玄参中有机氯农药残留主要为六六六、七氯、硫丹,制定的玄参有机氯农药残留限量标准为总有机氯≤0.700μg/g。Objective To obtain profile of residues of organochlorine pesticides in medicinal materials and decoction pieces of Scrophulariae Radix;To establish the limit standard for the residue of organochlorine pesticides.Methods Rapid gas chromatography was used to determine the residues of 21 organochlorine pesticides in medicinal materials of Scrophulariae Radix from ten producing areas of China and 30 batches of Scrophulariae Radix Decoction Pieces from seven producing areas. The 99% confidence interval was investigated, and the limit standard for organochlorine residue of Scrophulariae Radix was established. Results The determination of residues of 21 organochlorine pesticide in samples of Scrophulariae Radix was among 0.000 1–0.077 7 μg/g, and contents of BHC,heptachlor, and endosulfan occupying 93%–96% of total pesticide residue. The national industry standard for the limit of organochlorine pesticides was established. Conclusion The residues of organochlorine in Scrophulariae Radix are mainly BHC, heptachlor, and endosulfan. The limit standard of total organochlorine for Scrophulariae Radix was no higher than 0.700 μg/g.

关 键 词：玄参 有机氯 农药残留 限量标准 行业标准 

分 类 号：R284.1[医药卫生—中药学]