组织驻留淋巴细胞研究进展  

Research progress on tissue-resident lymphocytes

作　　者：周静[1] 彭慧[1] 田志刚[1] ZHOU Jing;PENG Hui;TIAN Zhi-Gang(Institute of Immunology,University of Science & Technology of China,Hefei 230027,China)

机构地区：[1]中国科学技术大学免疫学研究所

出　　处：《中国免疫学杂志》2019年第14期1665-1670,共6页Chinese Journal of Immunology

基　　金：国家自然科学基金(No.81788101,91542000)资助项目

摘　　要：淋巴细胞作为机体免疫系统的重要组成部分,以往被认为在淋巴组织和非淋巴组织之间循环迁移。近年来许多研究表明,机体中也存在多种不具有循环特性的组织驻留淋巴细胞,包括组织驻留记忆性T细胞(TRM)、固有淋巴样细胞(ILCs)和多种非传统的固有样T细胞。组织驻留淋巴细胞与循环性淋巴细胞除了组织迁移特性不同之外,表型与功能特征也存在诸多差异。本文根据已有文献,综述了组织驻留淋巴细胞的不同分类,并讨论了其发育特征及相应功能的研究进展。Lymphocytes are an important component of the immune system,previously considered to continuously recirculate between the lymphoid and nonlymphoid tissues.Recent findings show that a variaty of non-circulating tissue-resident lymphocytes are also present in the immune system,including tissue-resident memory T cells (TRM),innate lymphoid cells (ILCs) and several unconventional innate-like T cells.Apart from the mobility characteristic,many phenotypical and functional differences also exist between tissue-resident lymphocytes and circulating lymphocytes.Here,we review recent findings on the heterogeneity of tissue-resident lymphocytes,and discuss the research progress on their development and function.

关 键 词：组织驻留淋巴细胞 组织驻留记忆性T细胞 固有淋巴样细胞 固有样T细胞 

分 类 号：R392[医药卫生—免疫学]