妊娠期糖尿病患者血清vaspin水平变化及其与炎症因子关系的探讨  

Changes of serum vaspin levels in patients with gestational diabetes mellitus and its correlation with inflammatory factors

作　　者：朱慧静[1] 朱昕[1] 解合兰[1] 程霖[1] 张巧芹[2] 杨明明[1] ZHU Hui-jing;ZHU Xin;XIE He-lan(Department of Endocrinology, Heze Municipal Hospital, Shandong 274031, China)

机构地区：[1]菏泽市立医院内分泌科,山东274031 [2]菏泽市立医院产科,山东274031

出　　处：《中国临床新医学》2019年第7期736-739,共4页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

基　　金：荷泽市立医院科研项目(编号:20150302)

摘　　要：目的探讨妊娠期糖尿病(GDM)患者血清脂肪特异性丝氨酸蛋白酶抑制剂(vaspin)水平的变化及其与炎症因子肿瘤坏死因子α(TNF-α)、白介素6(IL-6)的相关性。方法选取2016-10~2017-12于菏泽市立医院产科门诊行常规产前检查的孕妇120例,按75g葡萄糖耐量试验(OGTT)结果,分为GDM组60例,糖耐量正常妊娠(GNGT)组60例。采用酶联免疫吸附法(ELISA)测定空腹血清vaspin、TNF-α、IL-6水平并进行统计学分析。结果GDM组血清vaspin、TNF-α、IL-6水平均显著高于GNGT组(P<0.05)。线性相关分析显示,vaspin与孕前体质量指数(BMI)、BMI增加幅度、血清胰岛素(FINS)、稳态模型胰岛素抵抗指数(HOMA-IR)呈显著正相关(P<0.05),与TNF-α、IL-6呈显著负相关(P<0.05)。多元线性回归分析显示,孕前BMI、TNF-α、IL-6和HOMA-IR是血清vaspin的独立影响因素(P<0.05)。结论GDM患者血清vaspin、TNF-α、IL-6水平均升高,vaspin可能代偿性参与了肥胖、胰岛素抵抗及GDM的发生发展,同时vaspin有抑制炎症反应的作用。Objective To explore the changes of serum vaspin levels in patients with gestational diabetes mellitus(GDM) and its correlation with inflammatory factors of tumor necrosis factor-alpha(TNF-α) and interleukin-6(IL-6). Methods One hundred and twenty pregnant women undergoing prenatal examination in the Obstetrical Out-patient Clinic of Heze Municipal Hospital from October 2016 to December 2017 were selected. The 120 pregnant women were divided into GDM group( n =60) and normal glucose tolerance(GNGT) group( n =60) according to their different oral glucose tolerance test(OGTT) results. The levels of fasting serum vaspin, TNF-α and IL-6 were detected by enzyme-linked immunosorbent assay(ELISA), and statistical analysis was conducted. Results The serum levels of vaspin, TNF-α and IL-6 in the GDM group were significantly higher than those in the GNGT group( P <0.05).Correlation analysis showed that vaspin was positively correlated with pre-gestational body mass index(BMI), increment of BMI during pregnancy, fasting insulin(FINS) and homeostasis model assessment of insulin resistance(HOMA-IR) but negatively correlated with TNF-α and IL-6( P <0.05). In a multiple linear regression analysis,pre-gestational BMI, TNF-α, IL-6 and HOMA-IR were independent risk factors of serum vaspin concentrations. Conclusion Serum levels of vaspin, TNF-α and IL-6 in GDM patients are increased. Vaspin may be compensatory in the occurrence and development of obesity, insulin resistance and GDM, and can inhibit the inflammatory response.

关 键 词：脂肪特异性丝氨酸蛋白酶抑制剂 妊娠期糖尿病 炎症因子 胰岛素抵抗 

分 类 号：R714[医药卫生—妇产科学]