伐地那非联合十一酸睾酮对糖尿病性勃起功能障碍患者雄激素及血管内皮功能的影响  

Effects of vardenafil combined with testosterone undecanoate on androgen and vascular endothelial function in patients with diabetic erectile dys-function

作　　者：马登扬[1] 孙霞[2] 刘安全[1] 顾腾飞 MA Dengyang;SUN Xia;LIU Anquan;GU Tengfei(Department of Urology,Lishui Central Hospital of Zhejiang Province,Lishui 323000,China;Department of Endocrinology,Lishui Central Hospital of Zhejiang Province,Lishui 323000,China)

机构地区：[1]浙江省丽水市中心医院泌尿外科,浙江丽水323000 [2]浙江省丽水市中心医院内分泌科,浙江丽水323000

出　　处：《中国现代医生》2019年第19期114-117,共4页China Modern Doctor

基　　金：浙江省医药卫生科技计划项目(2017KY729)

摘　　要：目的探讨伐地那非联合十一酸睾酮对糖尿病性勃起功能障碍(DMED)患者雄激素及血管内皮功能的影响.方法选择2015年1月~2018年6月就诊DMED患者84例,随机分为两组.两组均予伐地那非片10 mg,性生活前30 min口服.联合组加用十一酸睾酮40 mg,2次/d,口服,两组连用12周.观察治疗前后雄激素[总睾酮(TT)和游离睾酮(FT)]血管内皮功能指标[一氧化氮(NO)和内皮素-1(ET-1)]变化,并比较疗效.结果治疗12周后,两组血清TT和FT水平较前明显上升(P<0.05或P<0.01),且联合组上升幅度较对照组更明显(P<0.05);两组血清NO水平较前明显上升,血清ET-1水平较前明显下降(P<0.05或P<0.01),且联合组变化幅度较对照组更明显(P<0.05);同时联合组临床总有效率(95.24%)高于对照组(80.95%)(χ^2=4.09,P<0.05).结论伐地那非联合十一酸睾酮治疗DMED患者的疗效确切,能明显改善勃起功能,机制不仅能纠正雄激素缺乏,而且能调节血管内皮功能紊乱.Objective To investigate the effects of vardenafil combined with testosterone undecanoate on androgen and vascular endothelial function in patients with diabetic erectile dysfunction(DMED). Methods 84 patients with DMED who were admitted in the hospital from January 2015 to June 2018 were randomly divided into two groups. Both groups received 10 mg of vardenafil tablets orally 30 minutes before sex. The combined group was also treated with 40 mg of testosterone undecanoate twice daily for 12 weeks. The changes of androgen[total testosterone(TT)and free testosterone(FT)], vascular endothelial function indicators[total nitric oxide(NO) and endothelin-1(ET-1)] of before and after treatment were observed and compared. And the efficacy was compared. Results After 12 weeks of treatment, the levels of serum TT and FT in the two groups were significantly higher than those before(P<0.05 or P<0.01), and the increase in the combined group was more significant than that in the control group(P<0.05). The serum NO levels in the two groups were significantly higher than those before, and the level of serum ET-1 in both groups was significantly lower than that of the control group(P<0.05 or P<0.01), and the change of the combined group was more obvious than that of the control group(P<0.05). The total effective rate(95.24%) was higher in the combined group than that of the control group(80.95%)(χ^2=4.09, P<0.05). Conclusion Vardenafil combined with testosterone undecanoate is effective in the treatment of DMED patients, which can significantly improve erectile function. The mechanism can not only correct androgen deficiency, but also regulate endothelial dysfunction.

关 键 词：糖尿病 勃起功能障碍 伐地那非 十一酸睾酮 雄激素 血管内皮功能 

分 类 号：R587.2[医药卫生—内分泌] R698.1[医药卫生—内科学]