慢性阻塞性肺疾病与自噬相关性研究进展  

Advances in research on the relationship between chronic obstructive pulmonary disease and autophagy

作　　者：高璇 徐菲[2] 郑继生[1] 许先荣[1] GAO Xuan;XU Fei;ZHENG Jisheng;XU Xianrong(Department of Respiratory Medicine, Zhejiang Provincial Tongde Hospital, Hangzhou 310012, China;The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310006, China)

机构地区：[1]浙江省立同德医院呼吸内科,浙江杭州310012 [2]浙江大学医学院附属第一医院,浙江杭州310006

出　　处：《中国现代医生》2019年第18期164-168,共5页China Modern Doctor

基　　金：浙江省中医药科学研究基金项目(A类)(2018ZA020)

摘　　要：慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)是一种慢性进展性的肺部疾病,其发病机制包括气道慢性炎症、肺组织的破坏、肺重塑等。自噬是细胞内的一种分解代谢过程,大量研究提示,自噬与COPD的发生发展关系密切,而这一具体机制尚未得到阐明。本文将对COPD与自噬的相关性研究进展作一综述。Chronic obstructive pulmonary disease(COPD) is a chronic progressive lung disease, of which the pathogenesis includes chronic inflammation of the airways, destruction of lung tissue, and lung remodeling. Autophagy is a catabolic process in cells. A large number of studies suggest that autophagy is closely related to the occurrence and development of COPD, and this specific mechanism has not been elucidated. This article will review the research progress of the correlation between COPD and autophagy.

关 键 词：慢性阻塞性肺疾病 自噬 气道慢性炎症 肺重塑 

分 类 号：R563.9[医药卫生—呼吸系统]