杂化硅基手性色谱填料的制备及表征  

Preparation and characterization of hybrid-silica chiral stationary phase

作　　者：韩海峰[1] 范大双 王涛 张大兵[1] 尤慧艳[1,2] Han Haifeng;Fan Dashuang;Wang Tao;Zhang Dabing;You Huiyan(Jiangsu Hanbon Science and Technology Co., Ltd., Huai’an 223005, China;College of Environmental and Chemical Engineering, Dalian University, Dalian 116622, China)

机构地区：[1]江苏汉邦科技有限公司,淮安223005 [2]大连大学环境与化学工程学院,大连116622

出　　处：《分析仪器》2019年第4期37-43,共7页Analytical Instrumentation

基　　金：国家重大科学仪器设备开发专项(2013YQ170525);江苏省博士后科研资助计划(1701006C)

摘　　要：以1,2-二(三乙氧基硅基)乙烷(BTEE)和3-氨丙基三乙氧基硅烷(APTS)为原料,采用溶胶-凝胶法一步共聚制备杂化硅基填料,并通过水热法进一步扩孔。通过SEM、BET、IR、ICP以及MCT等仪器对合成的填料进行物理表征。在合成的氨基杂化介孔填料上进行手性涂覆,研制出纤维素-三(3,5-二甲基苯基氨基甲酸酯)修饰的杂化硅基手性色谱填料,对反式-二苯乙烯氧化物(TSO)、扁桃酸甲酯、黄烷酮、己唑醇等手性样品进行了分离,取得了良好的分离效果。Hybrid-silica was synthesized by co-condensation of 1,2-bis(triethoxysilyl)ethane(BTEE)and 3-aminopropyltriethoxysilane(APTS)through a sol-gel process.The pore size of the hybrid-silica was further enlarged by hydrothermal method.The prepared amino hybrid silica was characterized by SEM,BET,IR,ICP,MCT and Elemental analysis.The mixture of TSO,methyl mandelate,flavanone and hexaconazole were separated well on the hybrid-silica chiral stationary phase which was modified by cellulose-3(3,5-dimethyl phenylcarbamate)on the basis of the amino hybrid silica.

关 键 词：杂化硅基填料 手性色谱填料 液相色谱 

分 类 号：O652.6[理学—分析化学]