妊娠期抗抑郁药物的合理应用  

Rational Application of Antidepressants in Pregnancy

作　　者：翟倩 张国富 丰雷[1,2] ZHAI Qian;ZHANG Guofu;FENG Lei(Beijing Anding Hospital,Capital Medical University/The National Clinical Research Center for Mental Disorders/Beijing Key Laboratory of Mental Disorders,Beijing 100088,China;Advanced Innovation Center for Human Brain Protection/Capital Medical University,Beijing 100069,China)

机构地区：[1]首都医科大学附属北京安定医院国家精神心理疾病临床医学研究中心精神疾病诊断与治疗北京市重点实验室,北京市100088 [2]人脑保护高精尖创新中心首都医科大学,北京市100069

出　　处：《中国全科医学》2019年第24期2955-2961,共7页Chinese General Practice

基　　金：国家重点研发计划课题(2017YFC1311101)——精神心理疾病临床队列共享平台建设

摘　　要：妊娠期用药的研究受医学伦理学等因素的影响,迄今为止仍是临床药理学和药物研究发展最缓慢和最受忽视的领域之一。由于妊娠期独特的母体生理学变化和胎儿发育的易损性,使得妊娠期妇女的合理用药问题被广泛关注。抑郁症是一种慢性精神疾病,具有患病率高、致残率高、复发率高和自杀率高等特点,因此抑郁症妇女妊娠期抗抑郁药物应用的安全性及必要性,成为临床治疗面临的一大难题。本文主要就妊娠期抗抑郁药物的合理应用进行详述。The study of drug use during gestation is influenced by many factors other than medical ethics.It is still one of the most easily neglected fields with the slowest development in clinical pharmacology and pharmaceutical research.Due to unique changes in maternal physiology and the vulnerability of fetal development during pregnancy,rational use of drugs in pregnancy has been widely concerned.Depression is a kind of chronic mental disease characterized by high prevalence rate, high disability rate,high recurrence rate,and high suicide rate.Therefore,the safety and necessity of antidepressant use during pregnancy in depressed women has become a major problem in clinical treatment.This paper detailedly discusses the rational application of antidepressants in pregnancy.

关 键 词：妊娠 抗抑郁药 胚胎和胎儿发育 药物疗法 抑郁症 

分 类 号：R971.43[医药卫生—药品]