外周血T细胞受体删除环(TRECs)定量测定在评估骨髓移植术后免疫重建中的应用概况及进展  

Quantitative Determination of Peripheral Blood T Cell Receptor Rearrangement Excision Circle(TRECs) and Its Application and Progress in Evaluating Immune Reconstitution after Bone Marrow Transplantation

作　　者：武小亮 韩娟 王靖 卢林纲 WU Xiao-liang;HAN Juan;WANG Jing;LU Lin-gang(Food and Nutrition Assessment Lab,Institute of Food and Nutrition Development,Ministry of Agriculture,Beijing 100081,China)

机构地区：[1]农业农村部食物与营养发展研究所评价研究室

出　　处：《现代检验医学杂志》2019年第4期1-5,27,共6页Journal of Modern Laboratory Medicine

基　　金：国家自然科学基金项目(31802306);中国农业科学院创新工程项目(CAAS ASTIP32018IFND)

摘　　要：骨髓移植成功的关键在于移植后免疫系统的重建状况,特别是T细胞数量及功能的重建。T细胞受体删除环(TRECs)作为胸腺近期输出naive T细胞含量的标志,在细胞中十分稳定,可作为评价胸腺近期的输出功能及T细胞免疫重建状况的指标。鉴于TRECs对评价骨髓移植术后免疫重建状况具有重要现实意义,该文就TRECs的定量检测及其在评价骨髓移植后免疫重建状况中的应用概况及进展进行综述。The key to success of bone marrow transplantation depends on the immune reconstitution after transplantation, Especially the reconstruction of the number and function of T cells. T cell receptor rearrangement excision circle (TRECs) represent the number of naive T cell of thymus output,and are very stable in cells, which can be used as an index to evaluate the recent thymic emigrants and T cell immune reconstitution. In view of the important practical significance of TRECs in evaluating immune reconstitutionafter bone marrow transplantation. The article will review the quantitativedetection of TRECs and its application and progress in evaluation of immune reconstitution after bone marrow transplantation.

关 键 词：T细胞受体删除环(TRECs) 骨髓移植 免疫重建 

分 类 号：R457.7[医药卫生—治疗学] R392.4[医药卫生—临床医学]