SRC-3在犬乳腺癌中的表达及分析  

Expression and Analysis of SRC-3 in Canine Breast Cancer

作　　者：王华南 卫顺生[2] 高聪聪 马文[3] 裴世敏 杨旭[3] 张迪[3] 金艺鹏[3] 林德贵[3] WANG Hua-nan;WEI Shun-sheng;GAO Cong-cong;MA Wen;PEI Shi-min;YANG Xu;ZHANG Di;JIN Yi-peng;LIN De-gui(Department of Veterinary Medicine , College of Animal Sciences , Zhejiang University , Hangzhou 310058 , China;Institute of Animal Husbandry and Veterinary , Schiences of ShanXi Agricultural Academy , Taiyuan 030032 , China;College of Veterinary Medicine , China Agricultural University , Beijing 100193 , China)

机构地区：[1]浙江大学动物科学学院动物医学系,浙江杭州310058 [2]山西省农业科学院畜牧兽医研究所,山西太原030032 [3]中国农业大学动物医学院,北京海淀100193

出　　处：《中国兽医杂志》2019年第4期119-121,I0005,共4页Chinese Journal of Veterinary Medicine

基　　金：国家自然科学基金青年科学基金项目(31602118)

摘　　要：犬乳腺肿瘤是兽医临床常见的一种母犬肿瘤疾病。类固醇受体辅助活化因子-3(Steroid receptor activation factor3,SRC-3)与多种肿瘤的发生、发展、转移及预后密切相关,已成为一个潜在的用于癌症诊断的癌基因标记物。本试验通过免疫组化的方法,检测了从中国农业大学教学动物医院收集到的68例乳腺肿瘤组织SRC-3的表达情况。结果显示,犬恶性乳腺肿瘤组织中的SRC-3蛋白表达率高于正常与良性乳腺肿瘤组织。结果表明,SRC-3在恶性肿瘤里高表达,可以作为犬乳腺肿瘤疾病诊断的参考指标。Canine breast tumor is one of common tumor diseases in female dogs. Steroid receptor activation factor 3 (SRC-3) is closely related to the occurrence, development, metastasis and prognosis of multiple tumors, and has become a potential marker for cancer diagnosis. In this experiment, the expression of SRC-3 in 68 cases of canine mammarytumor was detected by immunohisto- chemistry. The results showed that the expression rate of SRC-3 protein in malignant breast tumor tissues was higher than that in normal tissues. The results show that SRC-3 is highly expressed in malignant tumors and can be used as a potential marker for the diagnosis of canine mammary cancer.

关 键 词：犬乳腺肿瘤 SRC-3蛋白 免疫组化 恶性肿瘤 良性肿瘤 

分 类 号：S858.292[农业科学—临床兽医学]