静脉输注免疫丙种球蛋白的不同给药方式治疗新生儿ABO溶血病的临床效果对比研究  

Comparative Study on the Clinical Efficacy of Different Mode of Administration of Intravenous Infusion of Immune Gamma Globulin in the Treatment of Neonatal ABO Hemolytic Disease

作　　者：张桂云 ZHANG Guiyun(Sichuan Jinxin Women and Children’s Hospital,Chengdu 610000,China)

机构地区：[1]四川锦欣妇女儿童医院成都市锦江区妇幼保健院金卡医院

出　　处：《中外医学研究》2019年第20期28-30,共3页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:研究通过两种给药方式静脉输注免疫丙种球蛋白用于新生儿ABO溶血病临床治疗中的效果。方法:选取笔者所在医院2017年4月-2018年4月新生儿ABO溶血病患儿80例,随机分为两组,分别接受不同给药方式,比较两组治疗效果。结果:观察组治疗后24、48、72 h总胆红素水平均低于对照组(P<0.05);观察组蓝光治疗、黄疸消退、住院时间均短于对照组(P<0.05);观察组治疗后贫血发生率、换血发生率分别为5.00%、2.50%,均低于对照组的20.00%、17.50%(P<0.05)。结论:选择单次高剂量静脉输注免疫丙种球蛋白治疗新生儿ABO溶血病能够获得更好的治疗效果,可推广。Objective:To study the effect of intravenous infusion of immune gamma globulin on the clinical treatment of neonatal ABO hemolytic disease by two modes of administration.Method:80 patients with ABO hemolytic disease from April 2017 to April 2018 in our hospital were randomly divided into two groups and received different mode of administration.The therapeutic effects of the two groups were compared.Result:The total bilirubin level in the observation group were lower than those of the control group at 24,48,and 72 hours after treatment(P<0.05).The blue light treatment,jaundice regression and hospitalization time in the observation group were shorter than those of the control group(P<0.05).The incidence of anemia and exchange blood were 5.00% and 2.50%,which were lower than 20.00% and 17.50% of the control group(P<0.05).Conclusion:The choice of single high-dose intravenous infusion of immune gamma globulin for the treatment of neonatal ABO hemolytic disease can obtain better therapeutic effects and can be promoted.

关 键 词：新生儿ABO溶血病 静脉输注 免疫丙种球蛋白 给药方式 治疗 

分 类 号：R722.18[医药卫生—儿科]