甲氧基取代苯甲醛缩硫代氨基脲芳基钌配合物的合成  

Synthesis of Methoxy-Benzaldehyde Thiosemicarbazone

作　　者：李培源 周泉 霍丽妮 贾智若 Li Peiyuan;Zhou Quan;Huo Lini;Jia zhiruo(College of Pharmacy,Guangxi University of Chinese Medicine,Nanning 530001,China;College of Chemistry and Materials Science,Nanning Normal University,Nanning 530001,China)

机构地区：[1]广西中医药大学药学院,广西南宁530001 [2]南宁师范大学化学与材料科学学院,广西南宁530001

出　　处：《山东化工》2019年第14期14-15,共2页Shandong Chemical Industry

基　　金：广西自然科学基金(2017GXNSFAA198335);壮瑶药协同创新中心(桂教科研[2013]20号);广西壮瑶药重点实验室(桂科基字[2014]32号);广西重点学科壮药学(桂教科研[2013]16号);广西一流学科中药学(民族药学)(桂教科研[2018]12号);广西中医药大学校级课题(2017JQ001);广西中医药大学中药学优势学科建设专项课题(ZYX2017003)

摘　　要：科研工作者围绕着芳基钌的配合物的合成、改性、作用靶点及作用机理等方面做了大量有意义的工作,有机金属钌氨基硫脲配合物的抗肿瘤性质成为研究热点。本论文采用邻甲氧基苯甲醛和3-硫代氨基脲反应制备邻甲氧基苯甲醛缩3-硫代氨基脲,将邻甲氧基苯甲醛缩3-硫代氨基脲作为配体与[Ru(p-cymene)Cl2]2反应制备配合物1,并研究其光谱特性。A lot of meaningful works about the synthesis,structure modification,target and mechanism of action have been done by scientist,therefore,the anticancer activity of ruthenium complexes has become a hot research topic.In this paper,o-methoxy benzaldehyde and 3-thiosemicarbazone were chosen to get o-methoxy benzaldehyde thiosemicarbazone,which further reacted with [Ru(p-cymene)Cl 2] 2 to produce complex 1.The spectral quality of compound 1 was investigated.

关 键 词：硫代氨基脲 苯甲醛 光谱性质 

分 类 号：O62[理学—有机化学]