126例重庆地区肺高血压患者的诊治现状分析  

Analysis of treatment and prognosis of 126 patients with pulmonary hypertension in Chongqing

作　　者：向涯洁 李卓霖 石文海[1] 黄翼[1] 王吴婉 王露[1] 宋小燕[1] 陈晓芳 周波[1] 刘启辰 曾小芳 李丹[1] 朱中凯 唐铭 何杨柯 李爱凌 董永洁 向睿[1] 封盼攀[1] 文莉[1] 黄玮[1] XIANG Yajie;LI Zhuolin;SHI Wenhai;HUANG Yi;WANG Wuwan;WANG Lu;SONG Xiaoyan;ZHOU Bo;LIU Qichen;ZENG Xiaofang;LI Dan;ZHU Zhongkai;TANG Ming;HE Yangke;LI Ailing;DONG Yongjie;XIANG Rui;FENG Panpan;WEN Li;HUANG Wei(Department of Cardiology,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China)

机构地区：[1]重庆医科大学附属第一医院心内科

出　　处：《重庆医学》2019年第14期2367-2372,共6页Chongqing medicine

基　　金：国家自然科学基金面上项目(81170188,30971212);重庆市自然科学基金一般项目(CSCT2009BB5069);重庆市卫生和计划生育委员会资助项目(2016HBRC001)

摘　　要：目的分析重庆地区肺高血压(PH)患者的临床特点、经济和营养状况、治疗和预后情况。方法选取2015年8月1日至2018年1月31日该院心内科门诊及住院的PH患者进行横断面调查研究并随访,超声心动图初筛,确诊方式为右心导管。结果500例患者经超声心动图初筛,126例患者行右心导管后确诊PH。原发疾病最常见的是先天性心脏病[30例(23.81%)]。60例(47.62%)患者有经济困难,80例(63.49%)患者存在营养风险。60例(47.62%)PH患者接受了PH靶向治疗,1年生存率和2年生存率分别为87.90%和84.00%,年龄(OR:8.23,95%CI:2.35~29.49,P=0.001)、PH靶向治疗(OR:0.28,95%CI:0.10~0.77,P=0.013)是PH患者死亡的保护因素。结论重庆地区PH患者的原发疾病主要以先天性心脏病为主,较小的年龄和接受PH靶向治疗是其死亡的保护因素。Objective To investigate the clinical characters,socioeconomic and nutrition conditions,treatment and prognosis of pulmonary hypertension(PH)in Chongqing.Methods From August 1 st 2015 to January 31 st 2018,PH patients admitted in the hospital were enrolled.PH was screened by echocardiography,the diagnosis was confirmed by right heart catheterization.Results A total of 500 patients were included in the echocardiographic screening,and 126 patients were diagnosed with PH by right heart catheterization.The most common primary disease was congenital heart disease[30 cases(23.81%)],60 cases(47.62%)had financial difficulties,and 80 cases(63.49%)had nutritional risks.Sixty cases(47.62%)with PH received PHtargeted therapy,one-year survival rate and two-year survival rate were 87.90% and 84.00%,respectively.The age(OR:8.23,95%CI:2.35-29.49,P=0.001)and PH-targeted therapy(OR:0.28,95%CI:0.10-0.77,P=0.013)was the protective factors.Conclusion The main etiologies of PH in Chongqing was congenital heart disease,young age and accepting PH-targeted therapy are protective factors for death.

关 键 词：高血压 肺性 疾病特征 经济 营养状况 生存率 

分 类 号：R543.2[医药卫生—心血管疾病]