髓源性抑制细胞在母胎耐受中的作用  

Role of myeloid-derived suppressor cells in maternal-fetal tolerance

作　　者：王一鸥 郭燕红[1] WANG Yi-ou;GUO Yan-hong(Department for Reproductive Medicine,the Third Hospital of Hebei Medical University,Shijiazhuang 050051)

机构地区：[1]河北医科大学附属第三医院生殖医学科

出　　处：《生殖医学杂志》2019年第8期970-975,共6页Journal of Reproductive Medicine

基　　金：河北省科技计划项目(17277776D).

摘　　要：髓源性抑制细胞(myeloid-derived suppressor cells,MDSCs)是具有免疫调节功能的髓系来源的细胞群。胚胎种植被视为一种半同种异体移植,成功妊娠的建立与维持需要母体免疫系统对含有父系抗原的胚胎有足够的免疫耐受。近年的研究显示正常妊娠孕妇MDSCs在外周血和母胎界面聚集,并促进母胎耐受的形成。本文就MDSCs在母胎耐受中的研究进展进行综述。Myeloid-derived suppressor cells(MDSCs)are a population of cells from bone marrow with immunosuppressive function.The implantation of embryo can be considered a“semi-allogeneic transplantation”.Thus,successful pregnancy requires maternal immune adaption to fetus with antigens derived from father.Recent studies have shown that MDSCs accumulate in peripheral blood and maternal-fetal interface of healthy pregnant women and promote the establishment of maternal-fetal tolerance.This paper summarizes the research progress and the role of MDSCs in maternal-fetal tolerance.

关 键 词：髓源性抑制细胞 母胎免疫耐受 妊娠 流产 子痫前期 

分 类 号：R714[医药卫生—妇产科学]