REM睡眠行为障碍的执行功能和自主神经功能障碍  

Executive and autonomic dysfunction inREM sleep behavior disorder

作　　者：黄小群 扎圣宇 陈捷[1] 李庆云[2] 李宁[2] 汤荟冬[1] 陈生弟[1] 马建芳[1] HUANG Xiaoqun;ZHA Shengyu;CHEN Jie(Department of Neurology & Co-innovation Center of Neuroregeneration,Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine,Shanghai 200025,China)

机构地区：[1]上海交通大学医学院附属瑞金医院神经内科,上海200025 [2]上海交通大学医学院附属瑞金医院呼吸内科,上海200025

出　　处：《中风与神经疾病杂志》2019年第7期604-608,共5页Journal of Apoplexy and Nervous Diseases

基　　金：国家自然科学基金(81571103)

摘　　要：目的 探讨快速眼动睡眠行为障碍(RBD)的认知和自主神经功能。方法 从2015年~2018年在上海瑞金医院共招募90例,其中包括经多导睡眠图诊断为RBD的患者30例(特发性RBD 17例,帕金森病伴RBD 13例),其他睡眠障碍30例(阻塞性睡眠呼吸暂停综合征13例,其他17例),健康对照30例。收集人口统计学特征,采用不同量表对睡眠、认知和自主神经功能进行评价。结果 认知功能测试显示,RBD组的连线测试B (Trail Making Test-B,TMT-B)表现最差。在亚组分析中,特发性RBD组在听觉词语学习测试(AVLT)中的表现较差。此外,RBD患者还表现出自主神经功能和焦虑情绪的损害。结论 RBD患者存在执行功能障碍和自主神经功能障碍。Objective To examine the cognitive and autonomic function of REM sleep behavior disorder (RBD). Methods A total of ninety people were recruited,including 30 RBD diagnosed by polysomnography (17idiopathic RBD and 13 RBD with Parkinson’s disease),30 other sleep disorders(13 obstructive sleep apnea (OSA) and 17 other sleep disorders) and 30 healthy controls,from 2015 to 2018 in Shanghai Ruijin hospital. Demographic features were collected and different scales were used to evaluate sleep,cognitive and autonomic function. Results RBD performed worst in Trail Making Test-B tests (TMT-B) among three groups. In subgroup analysis,iRBD showed worse performance in Auditory Verbal Learning Test (AVLT). RBD patients also demonstrated impairments in autonomic function and anxiety mood. Conclusions RBD showed executive dysfunction and autonomic dysfunction.

关 键 词：快速眼动行为障碍 执行功能障碍 自主神经功能障碍 阻塞性睡眠呼吸暂停 

分 类 号：R338.63[医药卫生—人体生理学]