糖尿病性多发性神经病神经传导异常与临床评分相关性分析  

Correlation between Nerve conduction and Michigan Neuropathy Screening Instrument in Diabetic polyneuropathy

作　　者：汪伟[1] 张雪莲[2] 邢小燕[2] 孙少杰[1] 汪仁斌[1] 焦劲松[1] WANG Wei;ZHANG Xuelian;XING Xiaoyan(Department of Neurology,China-Japan Friendship Hospital,Beijing 100029,China)

机构地区：[1]中日友好医院神经内科,北京100029 [2]中日友好医院内分泌科,北京100029

出　　处：《中风与神经疾病杂志》2019年第7期625-627,共3页Journal of Apoplexy and Nervous Diseases

基　　金：国家自然科学基金(No.8170051712)

摘　　要：目的 分析糖尿病性多发性神经病患者神经电生理改变及其与临床评分的相关性。方法 回顾性分析36例中日友好医院内分泌科住院的2型糖尿病性多发性神经病患者神经电生理异常特点并统计分析其与密歇根量表评分之间的相关性。结果 本研究入组的36例糖尿病性多发性神经病患者中,周围神经传导检查下肢重于上肢(100%vs83.3%),感觉传导异常比运动传导异常多见(100%vs83.3%),以下肢感觉传导感觉神经动作电位(SNAP)波幅下降最为常见(36/36,100%);运动神经传导异常则以运动传导速度(MCV)减慢相对常见(30/36,83.3%),复合肌肉动作电位(CMAP)波幅下降及运动传导远端潜伏期(DML)延长相对少见(11.1%,5.6%);神经损害电生理评分与密歇根量表评分之间具有显著相关(P<0.01)。结论 感觉传导波幅下降及轻度的运动传导速度减慢为常见的糖尿病性多发性神经病电生理改变特点;神经传导异常评分与密歇根量表评分具有显著相关,可用于疾病严重程度随访。Objective To study the nerve conduction abnormality and its relationship with Michigan Neuropathy Screening Instrument in Diabetic ployneuropathy patients. Methods We retrospectively analyzed the nerve conduction study and Michigan Neuropathy Screening Instrument (MNSI) in 36 in-house diabetic polynneuropathy patients between Jan 2015 to Dec 2016. Results In this retrospective study including 36 diabetic polyneuropathy patients,nerve conduction abnormalities are more common in lower limb than upper limb (100% vs 83.3%),sensory nerve abnormalities more common than motor (100% vs 83.3%),and decreased SNAP amplitude was present in all patients (36/36,100%);slowed MCV was the most common motor nerve abnormality;Nerve conduction study score (NCSS) statistically correlated with MNSI ( P < 0.01 ). Conclusion Decreased SNAP amplitude and mildly slowed MCV in lower and upper limbs are common in diabetic polyneuropathy;the combined score of nerve conduction abnormalities is correlated significantly with MNSI and could be a disease follow-up biomarker.

关 键 词：糖尿病 周围神经病 神经传导 密歇根量表 

分 类 号：R587.1[医药卫生—内分泌] R745[医药卫生—内科学]