雾化重组人干扰素α1b联合热毒宁对3～8岁儿童呼吸道合胞病毒感染肺炎的免疫学分析  

Immunological effects of atomization recombinant human interferon α1b combined with Reduning on pneumonia caused by respiratory syncytial virus infection in 3-8 years children

作　　者：韩晶[1] 赵志勇[2] 李贤伟[4] 张伟全[5] 李强[3] 任华[2] HAN Jing;ZHAO Zhiyong;LI Xianwei(Department of ICU, General Hospital of Jizhong Energy Fengfeng Group,Hebei, Handan 056002,China)

机构地区：[1]冀中能源峰峰集团总医院重症医学科,河北省邯郸市056002 [2]河北省邯郸市中心医院儿科二病区 [3]河北省邯郸市中心医院泌尿外科 [4]河北省邯郸市妇幼保健院 [5]河北省邯郸市第一医院

出　　处：《河北医药》2019年第15期2314-2317,共4页Hebei Medical Journal

摘　　要：目的研究雾化重组人干扰素α1b联合热毒宁对3~8岁儿童呼吸道合胞病毒感染所致肺炎的免疫学疗效。方法选取2016年1月至2018年1月接收治疗的3~8岁儿童呼吸道合胞病毒感染所致肺炎的患儿70例作为研究对象。采用随机数字表法将其随机分为A组(重组人干扰素α1b雾化治疗)和B组(重组人干扰素α1b雾化+热毒宁治疗),每组35例。观察2组患儿基线资料、血液免疫学指标、呼出气炎性因子表达、住院指标和不良反应发生情况。结果B组患儿治疗有效率(91.43%)显著高于A组(71.43%),差异有统计学意义(Z=13.652,P=0.000)。治疗后比较,B组患儿CD3^+、CD4^+、CD8^+和B细胞数改善程度均显著优于A组,差异有统计学意义(P<0.05)。2组患儿治疗后各项炎性因子在呼出气中表达量均显著下降,但B组患儿治疗后IL-1、IL-6、TNF-α和NF-κB的表达量均显著低于A组,差异有统计学意义(P<0.05)。B组患儿住院花销、治疗疗程、住院时间和症状消失时间均显著少于A组,差异有统计学意义(P<0.05)。2组患儿治疗过程中均无严重不良反应发生,且不良反应发生率比较,差异无统计学意义(χ^2=3.188,P=0.074)。结论雾化重组人干扰素α1b联合热毒宁对3~8岁儿童呼吸道合胞病毒感染所致肺炎的疗效较佳,能够显著改善免疫学指标,降低呼出气炎性因子表达,改善住院指标,安全可靠。Objective To investigate the immunological effects of atomization recombinant human interferonα1b combined with Reduning on pneumonia caused by respiratory syncytial virus infection in 3~8 years children.Methods Seventy children with pneumonia caused by respiratory syncytial virus infection in children aged 3~8 years who were treated from January 2016 to January 2018 were enrolled in the study,who were randomly divided into groupsA(recombinant human interferonα1b atomization treatment)and group B(recombinant human interferonα1b atomization+Reduning injection),with 35 cases in each group.The baseline data,blood immunological indexes,the expression levels of exhaled inflammatory factors,hospitalization indexes and the incidence rate of adverse reactions were observed and compared between the two groups.Results The effective rate in group B was 91.43%,which was significantly higher than that(71.43%)in group A(P<0.01).After treatment,the improvement degree of CD3^+,CD4^+,CD8^+and B cell counts in group B was significantly better than that in group A(P<0.05).The expression levels of inflammatory factors in exhaled breath were significantly decreased after treatment in both groups,moreover,the expression levels of IL-1,IL-6,TNF-αand NF-κB in group B were significantly lower than those in group A(P<0.05).The hospitalization expenses,treatment course,hospitalization time and symptom disappearance time in group B were significantly less than those in group A(P<0.05).In addition no severe adverse reactions were found during treatment in both groups,there was no significant diference between the two groups(P>0.05).Conclusion The atomization recombinant human interferonα1b combined with Reduning is effective in treatment of pneumonia caused by respiratory syncytial virus infection in children aged 3~8 years,which can significantly improve immunological indexes,reduce the expression levels of exhaled inflammatory factors,improve hospitalization indexes,with safety and reliability.

关 键 词：雾化重组人干扰素α1b 热毒宁 儿童 呼吸道合胞病毒 

分 类 号：R725.6[医药卫生—儿科]