不同年龄患者冻融D5单囊胚与双卵裂胚移植的妊娠结局比较  

Comparison of pregnancy outcomes between freeze-thaw D5 single blastocyst and double cleavage embryo transplantation in patients of different ages

作　　者：梁泳娜 彭宇洪[1] 张昭 钟树怀[1] 刘淑慎[1] LIANG Yong-na;PENG Yu-hong;ZHANG-Zhao;ZHONG Shu-huai;LIU Shu-shen(Department of Reproductive Medicine,Dongguan People′s Hospital,Guangdong Province,Dongguan 523059,China)

机构地区：[1]广东省东莞市人民医院生殖医学科

出　　处：《中国当代医药》2019年第20期57-60,共4页China Modern Medicine

摘　　要：目的比较不同年龄患者冻融D5单囊胚与双卵裂胚移植的妊娠结局。方法选择2016年2月~2018年2月在我院生殖中心接受冻融移植的患者作为研究对象,按照年龄的差异将其分为≤35岁组与>35岁组。其中≤35岁组包含单囊胚移植244个周期、双卵裂胚移植478个周期;>35岁组包含单囊胚移植83个周期、双卵裂胚移植343个周期。分别比较两组单囊胚移植以及双卵裂胚移植的临床妊娠率、种植率、多胎率、早产率、流产率及活产率。结果≤35岁组,单囊胚移植的临床妊娠率、种植率均明显高于双卵裂胚移植,多胎率明显低于双卵裂胚移植,差异有统计学意义(P<0.05);单囊胚移植与双卵裂胚移植的妊娠结局比较,差异无统计学意义(P>0.05)。>35岁组,单囊胚移植与双卵裂胚移植的临床妊娠率、种植率及妊娠结局比较,差异无统计学意义(P>0.05);单囊胚移植的多胎率明显低于双卵裂胚移植,差异有统计学意义(P<0.05)。结论≤35岁组选择性单囊胚移植优于双卵裂胚,>35岁组选择性单囊胚移植与双卵裂胚的妊娠结局无显著性差异,在D3可利用胚胎不多的情况下可以考虑双卵裂胚移植,然而在D3优质胚胎数>4个时仍选用选择性单囊胚移植以降低多胎率。Objective To compare the pregnancy outcomes between freeze-thawed D5 single blastocyst and double cleavage embryo transplantation in patients of different ages.Methods Patients who underwent freeze-thaw transplantation in reproductive center of our hospital from February 2016 to February 2018 were selected as subjects,and they were divided into ≤35 years old group and >35 year old group according to age differences.Among them,244 cycles of single blastocyst transplantation and 478 cycles of double cleavage embryo transplantation were included in the ≤35 years old group,83 cycles of single blastocyst transplantation and 343 cycles of double cleavage embryo transplantation were included in the >35 years old group.The clinical pregnancy rate,planting rate,multiple birth rate,preterm birth rate,abortion rate and live birth rate of single blastocyst and double cleavage embryo transplantation in the two groups were compared.Results In the ≤35 years old group,the clinical pregnancy rate and planting rate of single blastocyst transplantation were significantly higher than those of double cleavage embryo transplantation,the multiple birth rate was significantly lower than that of double cleavage embryo transplantation,and the differences were statistically significant (P<0.05).There were no significant differences in the pregnancy outcomes between the single blastocyst transplantation and double cleavage embryo transplantation in the ≤35 years old group (P>0.05).In the >35 years old group,the clinical pregnancy rate,planting rate and pregnancy outcomes of single blastocyst transplantation and double cleavage embryo transplantation were not significantly different (P>0.05).The multiple birth rate of single blastocyst transplantation was significantly lower than that of double cleavage embryo transplantation in the >35 years old group,and the difference was statistically significant (P<0.05).Conclusion The selective single blastocyst transplantation in ≤35 years old group is superior to double cleavage embryo tran

关 键 词：单囊胚移植 双卵裂胚移植 年龄 妊娠结局 

分 类 号：R711.6[医药卫生—妇产科学]