膝关节骨关节炎患病率及与骨质疏松症相关性研究  

Prevalence of degenerative knee osteoarthritis and its correlation with osteoporosis

作　　者：赵志宏[1] 王锐 国宇[1] 王恺[1] 蒋毅[3] 周敬滨[4] Zhao Zhihong;Wang Rui;Guo Yu;Wang Kai;Jiang Yi;Zhou Jingbin(Department of Orthopedics, Beijing Second Hospital, Beijing 100031, China;Department of sports Biomechanics, College of sports human science, Beijing sport university,Beijing 100084, China;Department of joint reconstructive surgery, Beijing Jishuitan Hospital, Beijing 100031, China;National Institute of Sports Medicine, Beijing 100061, China)

机构地区：[1]北京市第二医院骨科,100031 [2]北京体育大学运动人体科学学院运动生物力学教研室,100084 [3]北京积水潭医院矫形骨科,100035 [4]国家体育总局运动医学研究所,北京100061

出　　处：《中华骨科杂志》2019年第14期870-875,共6页Chinese Journal of Orthopaedics

摘　　要：目的了解北京地区18岁以上人群膝关节退行性骨关节炎流行病学特点,以及骨质疏松症与膝关节骨关节炎的相关性。方法采用横断面研究设计,并采用分层抽样的方法,抽取北京地区18岁以上常住人口,自行制定问卷(患病状况和可能影响因素)对研究对象进行面对面的问卷收集。膝关节退行性骨关节炎和骨质疏松症均为已在医院明确诊断的患者。首先对可能影响膝关节骨关节炎的因素进行单因素分析,然后多因素分析:控制性别、年龄、身体质量指数、腰臀比、教育水平、工作性质、工作强度、体育锻炼等因素的作用,采用Logistic多因素回归模型分析骨质疏松症对膝骨关节炎的独立作用。结果本组783例研究对象中,膝关节退行性骨关节炎53例,患病率为6.77%,患病率95%CI为(5.01%,8.53%)。<45岁组、45~59岁组和≥60岁组的患病率依次为2.54%、7.02%和16.67%,差异有统计学意义(χ^2=36.284,P=0.000)。在控制其他因素作用后,骨质疏松症对膝关节骨关节炎存在独立的影响(OR=3.56,95%CI:1.76,7.18)。结论年龄越大,退行性膝关节炎患病率越高;骨质疏松症与退行性膝关节炎存在相关性。Objective To investigate the prevalence of degenerative knee osteoarthritis and the relationship between osteoporosis and knee osteoarthritis. Methods A community-based cross-sectional study was conducted and stratified sampling method was used to select the sample. The permanent residents over 18 years old in Beijing were selected, and self-developed questionnaires were used by face-to-face interview including the disease condition and possible relative factors. The effect of osteoporosis on knee osteoarthritis was analyzed after controlling the effect of gender, age, BMI, waist-hip ratio, education level, nature of work, intensity of work, physical exercise by the Logistic regression model. Results Among the 783 subjects, 53 cases of knee degenerative osteoarthritis were found, with the prevalence rate was 6.77% and the prevalence rate of 95%CI was 5.01%, 8.53%. The prevalence rates of <45 years old group, 45-59 year-old group and ≥60-year-old group were 2.54%, 7.02% and 16.67% respectively, and the difference was statistically significant (χ^2=36.284, P=0.000). After controlling the other factors, osteoporosis had an independent effect on knee osteoarthritis with OR value of 3.56 (95%CI: 1.76, 7.18). Conclusion The older the age, the higher the prevalence of degenerative knee arthritis, and there is a correlation between osteoporosis and degenerative knee arthritis.

关 键 词：骨关节炎 膝 骨质疏松 患病率 横断面研究 

分 类 号：R580[医药卫生—内分泌] R684.3[医药卫生—内科学]