免疫细胞内的AKT/mTOR/STATs信号通路与多发性硬化症的研究进展  

AKT/mTOR/STATs signaling pathway regulates various immune cells that mediate MS

作　　者：张志康 翁勤洁[1] ZHANG Zhi-kang(reviewing);WENG Qin-jie(checking)(Zhejiang University College of Pharmaceutical Sciences,Hangzhou 310058,Zhejiang,China)

机构地区：[1]浙江大学药学院

出　　处：《医学研究生学报》2019年第7期771-775,共5页Journal of Medical Postgraduates

基　　金：国家杰出青年科学基金(81625024)

摘　　要：AKT/mTOR/STATs信号通路不仅在肿瘤生长中发挥重要的作用,也在免疫系统的调控中发挥重要作用,激活的AKT可以通过磷酸化促进下游信号通路mTOR复合物1和2的激活,而mTOR目前被认为是免疫系统的重要调控因子,在调控多种免疫细胞的功能及代谢上发挥着重要的作用。多发性硬化症是一种自身免疫缺陷性疾病,它的发病机制仍没有被完全阐明。文章着重对AKT/mTOR/STATs信号通路调控各类免疫细胞如:巨噬细胞M1/M2型极化,B细胞的增殖分化,辅助性T淋巴细胞的增殖和分化,调节性T淋巴细胞的增殖和分化作用机制进行阐述,进而说明AKT/mTOR/STATs信号通路在介导MS的免疫细胞调控中扮演的角色。AKT/mTOR/STATs signaling pathway not only plays an important role in tumor growth, but also in the regulation of immune system. Activated AKT promotes the activation of downstream signaling pathways mTORC1 and mTORC2 through phosphorylation. mTOR is currently being considered as an important regulator of immune system and plays an important role in regulating the function and metabolism of various immune cells. Multiple sclerosis (MS) is an autoimmune deficiency disease whose pathogenesis has not been fully elucidated. This article focuses on the regulation of AKT/mTOR/STATs signaling pathways in various immune cells such as macrophage M1/M2 polarization, B cell proliferation and differentiation, helper T lymphocyte (Th cell) proliferation and differentiation, and Treg cell proliferation and differentiation, which would be helpful to illustrate the role of the AKT/mTOR/STATs signaling pathway in mediating the regulation of immune cells in MS.

关 键 词：多发性硬化症 AKT/mTOR/STATs 辅助性T细胞 巨噬细胞极化 调节性T淋巴细胞 B细胞 

分 类 号：R392[医药卫生—免疫学]