TGF-β受体介导的信号转导通路与支气管哮喘研究进展  

Transforming growth factor β receptor mediated signal transduction pathway and bronchial asthma

作　　者：封广艺 李超乾 姜晓红[3] Feng Guangyi;Li Chaoqian;Jiang Xiaohong(Departmerit of Respiratory and Critical Care Medicine, the Sixth Affilated Hospital of Guangxi Medical University, Yulin 537000, China;Guangjci Medical College, Nanning 530023,China;Department of Geriatric Respiratory Disease, the First Affilated Hospital o f Guangxi Medical University, Nanning 530021, China)

机构地区：[1]广西医科大学第六附属医院呼吸与危重症医学科,玉林537000 [2]广西卫生职业技术学院,南宁530023 [3]广西医科大学第一附属医院老年呼吸科,南宁530021

出　　处：《国际呼吸杂志》2019年第14期1106-1109,共4页International Journal of Respiration

基　　金：广西壮族自治区卫生厅自筹经费科研课题(Z2O14O3O);2016年度广西急诊与医学救援人才小高地广西高校急诊医学重点实验室开放课题(GXJZ201601);广西医科大学青年科学基金项目(GXMUYSF201509).

摘　　要：支气管哮喘通常以气道慢性炎症为主要特征,其发病机制包括气道炎症、气道高反应性以及气道重塑等。转化生长因子β受体介导的信号转导通路在其中发挥了重要的作用,本文主要综述了近年来转化生长因子β受体介导的信号转导通路与支气管哮喘的关系进展。Bronchial asthma is generally characterized by chronic airway inflammation, its pathogenesis includes airway inflammation, airway hyperresponsiveness, airway remodeling and so on. The signal transduction pathway mediated by transforming growth factor β(TGF-β) receptor plays an important role in it. This paper mainly reviews the recent progress in the relationship between the signal transduction pathway mediated by TGF-β receptor and bronchial asthma.

关 键 词：哮喘 转化生长因子Β受体 信号转导 

分 类 号：R562.25[医药卫生—呼吸系统]