姜黄抗前列腺增生作用有效成分研究  

Study on Active Ingredients of Jianghuang(Curcumae Longae Rhizoma) against Prostatic Hyperplasia

作　　者：刘莉[1] 张璐[2] 王凯燕 张珍珍 徐桂红 林桂涛[1] LIU Li;ZHANG Lu;WANG Kaiyan;ZHANG Zhenzhen;XU Guihong;LIN Guitao(Shandong University of Traditional Chinese Medicine,Jinan 250355, China;Shandong University of Arts,Jinan 250300, China;Qihe County People's Hospital, Qihe 251100, China)

机构地区：[1]山东中医药大学,山东济南250355 [2]山东艺术学院,山东济南250300 [3]齐河县人民医院,山东齐河251100

出　　处：《山东中医杂志》2019年第7期689-693,共5页Shandong Journal of Traditional Chinese Medicine

基　　金：山东省重点研发计划重大关键技术及重点产业关键技术(编号:2016CYJS08A01-10)

摘　　要：目的:观察姜黄75%乙醇提取物对良性前列腺增生症模型小鼠前列腺增生的抑制效果,探讨姜黄抗前列腺增生作用的活性成分。方法:测定75%乙醇提取的姜黄不同溶剂萃取物中姜黄素的含量,并观察不同溶剂萃取物对良性前列腺增生症模型小鼠前列腺系数的影响。结果:姜黄素含量最高的乙醚萃取物与姜黄素含量最低的正丁醇萃取物均能降低小鼠前列腺系数,且两者治疗效果无明显差异(P> 0.05)。结论:姜黄75%乙醇提取物具有较好的治疗良性前列腺增生症的作用,除姜黄素外,其他成分也具有与姜黄素相似的抑制前列腺增生的作用。Objective: To observe the inhibitory effect of 75% ethanol extract of Jianghuang (Curcumae Longae Rhizoma) on prostatic hyperplasia of benign prostatic hyperplasia model mice and to explore the active ingredients of Jianghuang in inhibiting prostatic hyperplasia. Methods: The content of curcumin in different solvent extracts of Jianghuang extracted by 75% ethanol was determined and the effect of different solvent extracts on the prostate coefficient of the model mice with benign prostatic hyperplasia was observed. Results :Both ether extract with the highest curcumin content and n-butanol extract with the lowest curcumin content can reduce the prostate coefficient, and there was no significant difference between the effect of the two extracts. Conclusions: The 75% ethanol extract of Jianghuang has a good curative effect on benign prostatic hyperplasia. Besides curcumin, other ingredients have similar inhibitory effect on prostatic hyperplasia with curcumin.

关 键 词：姜黄 前列腺增生 前列腺系数 活性成分 小鼠 

分 类 号：R284.2[医药卫生—中药学]