细胞色素P4501A1的非芳香烃受体依赖调控机制及其在感染和炎症中作用的研究进展  

Non aromatic hydrocarbon receptor dependent regulatory mechanism of cytochrome P4501A1 and its role in infection and inflammation

作　　者：唐欣 陈涛 田李星 王星玉 刘宽 黄祺 梁华平 Tang Xin;Chen Tao;Tian Lixing;Wang Xingyu;Liu Kuan;Huang Qi;Liang Huaping(Department of Intensive Care Unit, the Affiliated Hospital of Zunyi Medical University, Zunyi 563003,Guizhou, China;State Key Laboratory of Trauma, Burns and Combined Injury, Research Institute of Surgery of the Third Affiliated Hospital, the Army Military Medical University, Chongqing 400042,China;Zunyi Medical University, Zunyi 563000, Guizhou, China)

机构地区：[1]遵义医科大学附属医院重症医学科,贵州遵义563003 [2]陆军军医大学第三附属医院野战外科研究所,创伤、烧伤与复合伤国家重点实验室,重庆400042 [3]遵义医科大学,贵州遵义563000

出　　处：《中华危重病急救医学》2019年第6期777-780,共4页Chinese Critical Care Medicine

基　　金：国家自然科学基金(81871612).

摘　　要：感染及炎症相关性疾病是目前威胁人类健康的重要病种,若未及时控制,患者将出现一系列并发症,如脓毒症、炎性因子"风暴"等,甚至导致死亡.在感染及炎症疾病的发展过程中,细胞色素P4501A1 (CYP1A1)经不同物质诱导,在不同的细胞及器官中通过芳香烃受体(AhR)依赖和非依赖途径发挥着关键作用.本文主要对CYP1A1的非AhR依赖调控机制及CYP1A1在感染和炎症中的不同作用进行综述,旨在为CYP1A1与感染及炎症关系的进一步研究提供参考.Infectious and inflammatory diseases are important diseases threatening human health. Without timely control, a series of complications will occur in patients, such as sepsis, inflammatory factor storm, and even lead to death. It has been found that cytochrome P4501A1 (CYP1A1) plays a key role in the development of infectious and inflammatory diseases through aromatic hydrocarbon receptor (AhR) dependent and non-dependent pathways in different cells and organs induced by different substances. The non AhR dependent regulatory mechanism of CYP1A1 and the different roles of CYP1A1 in infection and inflammation is reviewed in order to provide reference for further research on the relationship between CYP1A1 and infection and inflammation.

关 键 词：细胞色素P450 调控机制 感染 炎症 

分 类 号：R459.7[医药卫生—急诊医学]