钙化性主动脉瓣疾病代谢相关危险因素研究进展  

Research progress in metabolism risk factors of calcified aortic valvular disease

作　　者：王珊[1] 史嘉玮[1] 邓惠芳 刘星 WANG Shan;SHI Jia-wei;DENG Hui-fang;LIU Xing(Department of Cardiovascular Surgery,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China)

机构地区：[1]华中科技大学同济医学院附属协和医院心血管外科,湖北省武汉市430022

出　　处：《中国心血管病研究》2019年第7期580-584,共5页Chinese Journal of Cardiovascular Research

基　　金：国家自然科学基金面上项目(81770387).

摘　　要：钙化性主动脉瓣疾病(calcified aorticval vedisease,CAVD)是由多种因素引起的以主动脉瓣钙化为主要病理改变的退行性心脏瓣膜病,是中老年患者行主动脉瓣膜置换手术的最常见原因。一般认为CAVD可能危险因素与动脉粥样硬化相似。通过大样本前瞻性流行病学调査和回顾性研究,目前认为最具关联性的临床危险因素包括:年龄、性别、脂蛋白a等血脂异常、高血压、肥胖、糖尿病、肾功能不全等。本文就CAVD代谢相关危险因素的最新研究进展进行综述。Calcified aortic valve disease (CAVD) is a degenerative heart valve disease in which calcification of aortic valve is the main pathological change caused by various factors. It is the most common reason for the middle-aged and elderly patients to undergo valve replacement surgery. It is believed that the risk factors of CAVD are similar to atherosclerosis. In view of the large sample prospective epidemiological and retrospective studies, the most relevant clinical risk factors include age, gender, dyslipidemia like lipoprotein a, hypertension, obesity, diabetes and renal insufficiency. This article reviewed the latest research progress in metabolic risk factors related to CAVD.

关 键 词：钙化性主动脉瓣疾病 代谢 危险因素 

分 类 号：R542.52[医药卫生—心血管疾病]