围手术期应用体外培育牛黄对OSA患者H-UPPP手术后伤口恢复的疗效研究  

Study on the effect of in vitro cultured calculus bovis in perioperative period after H-UPPP operation

作　　者：邹哲飞 崔前波 谭健 杨琪 周兴星 袁琨[1] 陈伟[1] ZOU Zhefei;CUI Qianbo;TAN Jian;YANG Qi;ZHOU Xingxing;YUAN Kun;CHEN Wei(Department of Otolaryngology,the Central Hospital of Wuhan,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,430014,China)

机构地区：[1]华中科技大学同济医学院附属武汉市中心医院耳鼻咽喉科

出　　处：《临床耳鼻咽喉头颈外科杂志》2019年第7期639-642,646,共5页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

基　　金：武汉市卫健委基金项目(No:WX13B08)

摘　　要：目的:探讨OSA患者H-UPPP围手术期含服体外培育牛黄对术后口咽和体内炎症反应的作用。方法:选取确诊为OSA并符合行H-UPPP手术适应证的80例患者,采用随机数字表法将患者分成实验组和对照组,每组各40例。实验组给予体外培育牛黄含服,对照组不用。比较2组患者术后口咽部疼痛、恢复正常饮食的时间、局部水肿情况,唾液中IL-1β、IL-8和TNF-α浓度以及血液中IL-1β、IL-8、TNF-α浓度。结果:术后第3、5、7天口咽部疼痛情况实验组优于对照组(P<0.05),而术后第1天,2组之间咽部疼痛情况差异无统计学意义(P>0.05);术后实验组恢复正常饮食时间较对照组缩短(P<0.05);术后第5、7天口咽部水肿情况实验组优于对照组(P<0.05);术后第3、5、7天唾液中的IL-1β、IL-8和TNF-α水平实验组低于对照组(P<0.05);术后第5、7天血液中IL-1β、IL-8及TNF-α浓度实验组低于对照组(P<0.05)。结论:H-UPPP围手术期含服体外培育牛黄能改善患者术后咽痛和口咽局部水肿,缩短正常饮食的时间,降低口咽部及血液中相关炎症因子的表达。Objective:The aim of this study is to investigate the effect of in vitro cultured Calculus Bovis on the inflammation of oropharynx and body in patients with OSA during the perioperative period of H-UPPP.Method:Eighty patients with OSA and H-UPPP indications were enrolled.The patients were divided into experimental group and control group by random number table,40 cases in each group.The experimental group was given in vitro cultured Calculus Bovis,while the control group was not given bovine bezoar in vitro.The postoperative oropharyngeal pain,time to resume normal diet,local edema,concentration of IL-1β,IL-8 and TNF-αin saliva,and concentration of IL-1β,IL-8 and TNF-αin blood were compared between the two groups.Result:The pain of oropharynx in the experimental group was lighter than that in the control group on the 3 rd,5 th and 7 th day after operation(P<0.05),but there was no significant difference in the pain of oropharynx between the two groups on the 1 st day after operation(P<0.05);the time of restoring normal diet in the experimental group was shorter than that in the control group(P>0.05);the edema of oropharynx in the experimental group was lighter than that in the control group on the 5 th and 7 th day after operation(P<0.05).The levels of IL-1β,IL-8 and TNF-αin saliva were lower than those in control group on the 3 rd,5 th and 7 th day after operation(P<0.05),and the levels of IL-1β,IL-8 and TNF-αin blood on the 5 th and 7 th day after operation were lower than those in control group(P<0.05).Conclusion:In vitro perioperative period of H-UPPP can improve the postoperative sore throat and local edema of oropharynx,shorten the time of normal diet and reduce the expression of related inflammatory factors in oropharynx and blood.

关 键 词：睡眠呼吸暂停 阻塞性 体外培育牛黄 改良悬雍垂腭咽成形术 术后疼痛 

分 类 号：R763[医药卫生—耳鼻咽喉科]