27-羟基胆固醇与乳腺导管原位癌相关性研究  

Correlation between 27-hydroxy cholesterol and ductal carcinoma in situ

作　　者：张雅媛[1] ZHANG Ya-yuan(Department of Thyroid Breast Surgery,Second Clinical Medical College of Jinan University,Shenzhen People’s Hospital,Shenzhen 518000,Guangdong Province,China)

机构地区：[1]暨南大学第二临床医学院,深圳市人民医院甲状腺乳腺外科

出　　处：《中国临床药理学杂志》2019年第14期1431-1434,共4页The Chinese Journal of Clinical Pharmacology

基　　金：广东省医学科学技术研究基金资助项目(A201 6490)

摘　　要：目的观察27-羟基胆固醇与乳腺导管原位癌临床病理及预后的相关性。方法入选拟进行手术治疗的125例乳腺导管原位癌患者,术前抽取空腹周静脉血,用酶联免疫吸附(ELISA)试剂盒测定血清27-羟基胆固醇水平,并以125例健康志愿者为对照;术中留取癌组织和癌旁健康组织,用ELISA试剂盒测定组织27-羟基胆固醇水平。统计患者临床和随访资料,分析27-羟基胆固醇与患者病理特征及预后的关系。结果乳腺导管原位癌患者血清27-羟基胆固醇水平为(0. 85±0. 32)μmol·L^-1,健康志愿者为(0. 44±0. 15)μmol·L^-1,差异有统计学意义(P <0. 05)。乳腺导管原位癌患者癌组织27-羟基胆固醇水平为(0. 88±0. 14)μmol·g^-1,癌旁健康组织为(0. 22±0. 08)μmol·g^-1,差异有统计学意义(P <0. 05)。乳腺导管原位癌患者术后3年死亡率为16. 8%,血清和组织27-羟基胆固醇的ROC曲线下面积(AUC)分别为0. 804和0. 854;术后3年复发或转移率为31. 2%,血清和组织27-羟基胆固醇的AUC分别为0. 692和0. 777。结论乳腺导管原位癌患者的27-羟基胆固醇水平对患者预后具有较高的预测价值。Objective To explore the relationship between 27 - hydroxy cholesterol and clinical pathology and prognostic of patients with ductal carcinoma in situ. Methods Totally 125 patients with ductal carcinoma in situ and prepared to be treated with surgery were selected,whose venous blood was extracted to detect 27 - hydroxy cholesterol using enzyme - linked immunosorbent assay ( ELISA) kits before treatment,and 125 healthy volunteers were also selected as the control. Both cancer tissue and healthy tissue of the patients were extracted to detect 27 - hydroxy cholesterol using ELISA kits too. The clinical and follow - up data of patients were recorded to analyze the relationship between 27 - hydroxy cholesterol and pathology characters and prognostic. Results The serum 27 - hydroxycholesterol level in patients with breast ductal carcinoma in situ was ( 0. 85 ± 0. 32)μmol·L^-1,and that in healthy volunteers was ( 0. 44 ± 0. 15)μmol·L^-1,with significant difference ( P < 0. 05). The tissue level of 27 - hydroxyl cholesterol was ( 0. 88 ± 0. 14)μmol·g^-1 in the breast ductal carcinoma in situ patients and ( 0. 22 ± 0. 08 )μmol·g^-1 in the adjacent healthy tissues,with significant difference ( P < 0. 05). The mortality rate in 3 years after surgery was 16. 8%,and the area under the ROC ( AUC) curve of serum and tissue 27 - hydroxy cholesterol were 0. 804 and 0. 854 respectively. The recurrence and metastasis rate in 3 years after surgery was 31. 2%,and the AUC of serum and tissue 27 - hydroxy cholesterol were 0. 692 and 0. 777 respectively. Conclusion The 27 - hydroxy cholesterol levels of ductal carcinoma in situ have high prognostic value for the prognosis of patients.

关 键 词：27-羟基胆固醇 乳腺导管原位癌 临床病理 预后 

分 类 号：R97[医药卫生—药品]