杞菊地黄汤加减辅助治疗妊娠期高血压疗效观察  

Effect of Qiju Dihuang Decoction Combined with Western Medicine in Treatment of Gestational Hypertension

作　　者：黄楠[1] 林珍云[2] HUANG Nan;LIN Zhenyun(The Affiliated Hospital of Hangzhou Normal University,Hangzhou 310015,Zhejiang,China;Hangzhou First People's Hospital,Hangzhou 310006,Zhejiang,China)

机构地区：[1]杭州师范大学附属医院,浙江杭州310015 [2]杭州市第一人民医院,浙江杭州310006

出　　处：《中华中医药学刊》2019年第7期1734-1736,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：浙江省医药卫生一般研究计划项目(2013KYA154)

摘　　要：目的:观察杞菊地黄汤加减与西药结合治疗妊娠期高血压的临床疗效。方法:选取妊娠期高血压的患者82例,并将其随机分为观察组与对照组,对照组41例,单纯采用硝苯地平缓释片治疗;观察组41例,在对照组的基础上给予杞菊地黄汤加减联合治疗。观察两组治疗效果。结果:观察组临床治疗总有效率明显较对照组高(P<0.05),治疗前两组血压及凝血酶指标均无显著差异(P>0.05),治疗后两组血压、血肌酐(Cr)、血尿素氮(BUN)、尿微量清蛋白(MA)、尿β2-微球蛋白(β2-MG)及凝血酶相关指标均较治疗前显著改善(P<0.05),且治疗后观察组血压、PT、APTT、Fib、Cr、BUN、MA、β2-MG均明显较同时期的对照组优,两组数据差异具有统计学意义(P<0.05);治疗后两组心电图、血常规、尿常规及肝肾功能均无明显异常,观察组不良反应发生率显著低于对照组,两组数据存在统计学差异(P<0.05)。结论:运用杞菊地黄汤加减结合西药治疗妊娠期高血压临床疗效显著,可有效降低患者高血压,促进凝血酶及肾功能的改善,缓解患者的临床症状,且患者引起不良反应较少,值得临床运用推广。Objective:To observe the clinical efficacy of Qiju Dihuang Decoction combined with western medicine in the treatment of gestational hypertension. Methods:Totally 82 cases of pregnancy-induced hypertension were selected and randomly divided into observation group and control group. In the control group, 41 cases were treated with nifedipine sustained-release tablets alone. The observation group’s 41 cases, on the basis of the control group were given Qiju Dihuang Decoction. We observed two groups’ treatment effect. Results:The total effective rate of the observation group was significantly higher than that in the control group(P<0.05). There was no significant difference in blood pressure or thrombin before treatment between two groups(P>0.05). BUN, MA,β2-MG and thrombin were all significantly improved(P<0.05). After treatment, the blood pressure, PT, APTT, Fib, Cr, BUN, MA and β2-MG were significantly better than those of the control group at the same period and the difference between the two groups was statistically significant(P<0.05). ECG, blood, urine Routine and liver and kidney function had no significant abnormalities. The adverse reactions in the observation group were significantly less than that of the control group and there was a statistically significant difference between the two groups(P<0.05). Conclusion:The treatment of pregnancy-induced hypertension with Qiju Dihuang Decoction combined with western medicine has significant clinical curative effect, which can effectively reduce the patients’ hypertension, promote the improvement of thrombin and renal function, relieve the clinical symptoms of patients and cause fewer adverse reactions, worthy of clinical application promotion.

关 键 词：妊娠期高血压 杞菊地黄汤 硝苯地平 

分 类 号：R714.246[医药卫生—妇产科学]