尿毒清颗粒联合左卡尼汀注射液治疗急性肾衰竭浊瘀阻塞证的临床研究  

Clinical study of Niaoduqing granules combined with levocarnitine injection in the treatment of acute renal failure with turbid blood stasis obstruction syndrome

作　　者：岳英丽[1] 陈珊珊[1] 窦晓丽[1] YUE Yingli;CHEN Shanshan;DOU Xiaoli(Department of Renal Medicine, Langfang People's Hospital, Langfang, Hebei 065000)

机构地区：[1]河北省廊坊市人民医院肾内科

出　　处：《河北中医》2019年第6期880-885,共6页Hebei Journal of Traditional Chinese Medicine

基　　金：廊坊市科学技术研究与发展计划自筹经费项目(编号:2013013026)

摘　　要：目的观察尿毒清颗粒联合左卡尼汀注射液治疗急性肾衰竭浊瘀阻塞证的临床疗效。方法将91例急性肾衰竭浊瘀阻塞证患者,按随机数字表法分为2组。2组均给予西医常规治疗,对照组45例加用左卡尼汀注射液治疗;治疗组46例加用尿毒清颗粒联合左卡尼汀注射液治疗。2组均治疗4周后统计疗效,并比较2组治疗前后中医症状评分(包括小便不利、小腹胀满、小腹疼痛及舌质紫黯或伴瘀斑)、肾功能相关指标[包括血肌酐(Cr)、尿素氮(BUN)、24h尿蛋白定量、24h尿微量白蛋白及尿β2微球蛋白(β2-MG)]、血流变学指标[全血黏度(高切)、全血黏度(中切)、全血黏度(低切)及血浆黏度]及氧化指标[血清超氧化物歧化酶(SOD)、黄嘌呤氧化还原酶(XOR)、谷胱甘肽过氧化物酶(GSH-Px)及丙二醛(MDA)]水平变化情况,并观察比较2组治疗期间不良反应发生情况。结果治疗组总有效率93.48%,不良反应发生率23.91%,对照组总有效率75.56%,不良反应发生率44.44%,治疗组总有效率高于对照组(P<0.05),不良反应发生率低于对照组(P<0.05);2组治疗后中医症状小便不利、小腹胀满、小腹疼痛及舌质紫黯或伴瘀斑评分与本组治疗前比较均明显降低(P<0.05),且治疗组均低于对照组(P<0.05);2组治疗后肾功能相关指标Cr、BUN、24h尿蛋白定量、24h尿微量白蛋白及尿β2-MG水平与本组治疗前比较均明显降低(P<0.05),且治疗组均低于对照组(P<0.05);2组治疗后血液流变学指标全血黏度(高切)、全血黏度(中切)、全血黏度(低切)及血浆黏度水平与本组治疗前比较均明显降低(P<0.05),且治疗组均低于对照组(P<0.05);2组治疗后氧化指标与本组治疗前比较,SOD、GSH-Px水平均明显升高(P<0.05),XOR、MDA水平均明显降低(P<0.05),且治疗组治疗后对各氧化指标水平改善均优于对照组(P<0.05)。结论尿毒清颗粒联合左卡尼汀注射液治疗急性肾衰竭浊瘀阻塞证可提�Objective To observe the clinical efficacy of Niaoduqing granules combined with levocarnitine injection in the treatment of acute renal failure with turbid blood stasis obstruction syndrome. Methods 91 cases of acute renal failure with turbid blood stasis obstruction syndrome were divided into two groups according to random number table method. Both groups were treated by routine western medicine. 45 cases in control group were treated by levocarnitine injection. 46 cases in treatment group were treated by Niaoduqing granules combined with levocarnitine injection. Both groups were treated for 4 weeks. The scores of TCM symptoms (including inhibited urination, abdominal distension, abdominal pain, tongue purple or with ecchymosis), renal function related indexes(including serum creatinine (Cr), urea nitrogen (BUN), 24-hour urinary protein quantification, 24-hour urinary microalbumin and urinary β 2-microglobulin (β 2-MG), blood rheology indexes [whole blood viscosity (high shear), whole blood viscosity (medium shear), whole blood viscosity (low shear) and plasma viscosity] and oxidation indexes [serum superoxide dismutase (SOD), xanthine oxidoreductase (XOR), glutathione peroxidase (GSH-Px) and malondialdehyde (MDA)] were compared between the two groups before and after treatment. The occurrence of adverse reactions between the two groups during treatment were observed and compared. Results The total effective rate was 93.48% in treatment group and 75.56% in control group,the incidence of adverse reactions was 23.91% in treatment group and 44.44% in control group.The total effective rate of the treatment group was higher than that of the control group ( P <0.05), and the incidence of adverse reactions was lower than that of the control group ( P <0.05). After treatment, the scores of TCM symptoms such as inhibited urination, abdominal distension, abdominal pain, tongue purple or with ecchymosis in both groups were significantly lower than those in the group before treatment ( P <0.05), and the treatment group wa

关 键 词：急性肾损伤 肾功能不全 中西医结合疗法 中成药 

分 类 号：R256.59[医药卫生—中医内科学] R692.5[医药卫生—中医学]