具有农药活性的微生物源核苷类化合物  

Agroactive Nucleosides from Microorganisms

作　　者：柯少勇[1] 吴兆圆 万中义[1] 方伟[1] 张亚妮[1] 王开梅[1] Shaoyong Ke;Zhaoyuan Wu;Zhongyi Wan;Wei Fang;Yani Zhang;Kaimei Wang(Hubei Biopesticide Engineering Research Centre,Hubei Academy of Agricultural Sciences,Wuhan 430064,China)

机构地区：[1]湖北省生物农药工程研究中心湖北省农业科学院

出　　处：《化学进展》2019年第7期954-968,共15页Progress in Chemistry

基　　金：国家重点研发计划项目(No.2017YFD0201205);湖北省农业科技创新资金项目(No.2016-620-000-039)资助~~

摘　　要：微生物天然产物在新农药的研究与开发中占据着重要的地位。核苷作为一类重要的生理活性物质,具有丰富多样的结构及生物活性。本文对微生物来源的具有农药活性的核苷类化合物进行总结,重点综述了具有农药活性的微生物源嘧啶或嘌呤、核苷及其衍生物及核苷酸类似物等三类微生物源核苷类化合物,分别对其来源、结构多样性、农药活性及杀虫、杀菌及抗病毒作用机制进行了概括,以期对新型农用抗生素的开发及新农药创制提供一些有益的借鉴。Microbial natural products play important roles in research and development of new agrochemicals. As a group of important physiologically active compounds, nucleosides from microorganisms have very diverse structures and bioactivities. This review summarizes the agroactive nucleosides from different microorganisms in three categories: nucleoside bases, nucleosides and derivatives, and the nucleotides. It mainly focuses on the producing microorganisms, the structural diversity, agroactivities, including the mode of actions of insecticidal, fungicidal, and antiviral activities. The authors hope that it will benefit the development of new agricultural antibiotics and new agrochemicals.

关 键 词：微生物核苷 结构多样性 杀虫活性 杀菌活性 除草活性 抗病毒活性 作用机制 

分 类 号：O626[理学—有机化学] Q524[理学—化学]