探讨静脉泵注右美托咪定对剖宫产产妇术中、术后及新生儿的影响  

Discussion on effect of intravenous infusion of dexmedetomidine on cesarean section women during and after operation and neonates

作　　者：李海洋[1] 漆冬梅[1] 李永乐[1] 黄希照[1] 黎昆伟[1] LI Hai-yang;QI Dong-mei;LI Yong-le(Department of Anesthesia,Guangdong Maternal and Child Health Hospital,Guangzhou 511400,China)

机构地区：[1]广东省妇幼保健院麻醉科

出　　处：《中国实用医药》2019年第21期86-88,共3页China Practical Medicine

摘　　要：目的研究静脉泵注右美托咪定对剖宫产产妇术中、术后以及新生儿的影响。方法54例剖宫产产妇,随机分为参照组与实验组,每组27例。参照组给予静脉泵注生理盐水,实验组给予静脉泵注右美托咪定。比较两组术前(T1)、药物输注10 min(T2)、新生儿娩出(T3)、手术完成(T4)时间段心率、平均动脉压、新生儿分娩2、5 min后阿氏(Apgar)评分以及产妇围术期不良反应发生情况。结果两组产妇T1心率、平均动脉压比较,差异无统计学意义(P>0.05)。实验组T2、T3、T4时间段心率、平均动脉压均显著优于参照组,差异有统计学意义(P<0.05)。实验组新生儿分娩后2、5 min Apgar评分分别为(9.71±0.38)、(9.94±0.19)分,参照组分别为(9.88±0.28)、(9.87±0.27)分,比较差异无统计学意义(P>0.05)。实验组产妇不良反应率为18.52%,低于参照组的25.93%,但差异无统计学意义(P>0.05)。结论剖宫产产妇静脉泵注右美托咪定效果显著,可有效改善心率,稳定平均动脉压,值得临床推广。Objective To study the effect of intravenous infusion of dexmedetomidine on cesarean section women during and after operation and neonates. Methods A total of 54 cesarean section women were randomly divided into control group and experimental group, with 27 cases in each group. The control group received intravenous infusion of normal saline, and the experimental group received intravenous infusion of dexmedetomidine. Comparison were made on heart rate and mean arterial pressure before operation(T1), 10 min after infusion(T2), neonatal delivery(T3) and operation completion(T4), Apgar score after 2 and 5 min of delivery and occurrence of perioperative adverse reactions between the two groups. Results Both groups had no statistically significant difference in heart rate and mean arterial pressure at T1(P>0.05). The experimental group had significantly better heart rate and mean arterial pressure at T2, T3 and T4(P<0.05). The experimental group had Apgar score after 2 and 5 min of delivery respectively as(9.71±0.38) and(9.94±0.19) points, which were(9.88±0.28) and(9.87±0.27) points in the control group. The difference was not statistically significant(P>0.05). The experimental group had lower incidence of adverse reactions as 18.52% than 25.93% in the control group, but the difference was not statistically significant(P>0.05). Conclusion Dexmedetomidine shows remarkable effect for cesarean section women, and it can effectively improve heart rate and stable mean arterial pressure. It is worthy of clinical promotion.

关 键 词：右美托咪定 剖宫产 不良反应 

分 类 号：R614[医药卫生—麻醉学]