基于GMO的立方晶前体溶液液体栓塞剂相态转变过程的研究  

Study on Phase Transformation Behavior of Liquid Embolic Agents Based on the Precursor Solutions of Cubic Crystal of Glyceryl Monooleate

作　　者：杜玲然 严立标 黄剑文 余宗峻 杨海南 黄玉刚 李旭丰 DU Ling-ran;YAN Li-biao;HUANG Jian-wen;YU Zong-jun;YANG Hai-nan;HUANG Yu-gang;LI Xu-feng(Key Laboratory of Molecular Target & Clinical Pharmacology,School of Pharmaceutical Sciences,The Second AffiliatedHospital of Guangzhou Medical University,Guangzhou Medical University,Guangzhou 511436,Guangdong,China)

机构地区：[1]广州医科大学药学院分子靶标与临床药理学重点实验室广州医科大学附属第二医院

出　　处：《合成材料老化与应用》2019年第4期10-14,共5页Synthetic Materials Aging and Application

基　　金：国家自然科学基金(81803460);广东省自然科学基金(2015A030310037);广东省医学科研基金(A2017069);广州市教育局科研基金(1201610085; 1201430509)

摘　　要：实验通过乙醇扩散、甘油单油酸酯(GMO)吸水动态研究3种前体溶液液体栓塞剂在过量水中从液体转化为凝胶的过程,在相图中绘制其变化趋势。采用偏光显微镜(PLM)、小角射线衍射(SAXS)和流变学方法鉴别各凝胶样品的相态。结果证实,基于GMO的立方晶前体溶液液体栓塞剂在过量水中均可以转化成Pn3m立方晶相凝胶。To investigate the phase transformation behavior from liquid into gel of three liquid embolic agents based on the precursor solutions of cubic crystal of glyceryl monooleate(GMO)in the excess water by measurement of ethanol diffusion and water uptake of GMO.The trend curves were drawn in the ternary phase diagram.The phase state was determined through polarized light microscopy(PLM),small angle X-ray scattering(SAXS)and rheological method.The results proved three liquid embolic agents based on the precursor solutions of cubic crystal of GMO could transform into gel with Pn3m cubic phase in the excess water.

关 键 词：甘油单油酸酯 立方晶 液体栓塞剂 相态转变 

分 类 号：R944.9[医药卫生—药剂学]