妊娠期肝内胆汁淤积症的联合用药治疗及远期效果评价  

Evaluation of long-term efficacy of combined medication for intrahepatic cholestasis of pregnancy

作　　者：陈彦 Chen Yan(Central Town Health Center, Wusheng County, Sichuan Province,Sichuan Guagan 638400,China)

机构地区：[1]四川省武胜县中心镇卫生院

出　　处：《实用妇科内分泌电子杂志》2019年第17期1-2,6,共3页Electronic Journal of Practical Gynecological Endocrinology

摘　　要：目的探讨妊娠期肝内胆汁淤积症的联合用药治疗及远期效果。方法将100例患者随机分为参比组和联合组,参比组实施常规药物熊去氧胆酸治疗,联合组则实施常规药物熊去氧胆酸+腺苷蛋氨酸治疗,对比两组临床效果。结果联合组妊娠期肝内胆汁淤积症疗效、症状改善的平均时间、平均住院的平均时间、新生儿Apgar测评值、肝功能的相关指标天门冬氨酸氨基转移酶、总胆汁酸、丙氨酸氨基转移酶以及总胆红素相比较参比组更好,P<0.05。联合组新生儿窒息、新生儿窘迫、早产以及剖宫产的发生率和参比组比较更低,P<0.05。结论常规药物熊去氧胆酸+腺苷蛋氨酸治疗妊娠期肝内胆汁淤积症效果确切,可获得理想效果,改善妊娠结局以及肝功能。Objective To investigate the long-term effect of combined medication for intrahepatic cholestasis of pregnancy. Methods 100 patients were randomly divided into the reference group and the combined group. The reference group was treated with ursodeoxycholic acid, while the combined group was treated with ursodeoxycholic acid and adenosylmethionine. The clinical effects of the two groups were compared. Results Compared with the control group, the combined group had better effects on intrahepatic cholestasis of pregnancy, the average time of symptoms improvement, the average time of hospitalization, the Apgar value of newborns, the related indicators of liver function, aspartate aminotransferase, total bile acid, alanine aminotransferase and total bilirubin, P<0.05. The incidence of neonatal asphyxia, neonatal distress, premature delivery and cesarean section in the combined group was lower than that in the control group (P<0.05). CONCLUSION Ursodeoxycholic acid plus adenosylmethionine is effective in the treatment of intrahepatic cholestasis of pregnancy, and can achieve ideal results, improve pregnancy outcomes and liver function.

关 键 词：妊娠期肝内胆汁淤积症 联合用药治疗 远期效果 

分 类 号：R714.25[医药卫生—妇产科学]